Long Term Outcomes of Relapsed/Refractory Non-Hodgkin Lymphoma: A Single Center Experience | ||||
| Egyptian Journal of Hematology and Bone Marrow Transplantation | ||||
| Volume 11, Issue 12, March 2024, Page 1-2 | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/ejhbmt.2024.345195 | ||||
 View on SCiNiTO | ||||
| Authors | ||||
| Fady Hennawy* ; Essam Abdel Wahed; Nour EL Hoda Abdallah; Rania Radwan | ||||
| Department of Hematology, Faculty of Medicine, Ain shams University | ||||
| Abstract | ||||
| Long Term Outcomes of Relapsed/Refractory Non-Hodgkin Lymphoma:
A Single Center Experience Fady Sobhy Kamal Hennawy, Essam Abdel Wahed, Nour El Hoda Hussein Abdallah, Rania Abdel Monem Radwan Department of Hematology, Faculty of Medicine, Ain shams University Corresponding author: Fady Sobhy Kamal Hennawy e-mail: fady.hennawy@med.asu.edu.eg, Phone: 01223633239 Abstract Background: Relapsed/refractory non-Hodgkin lymphoma, without a standard salvage regimen, represent a challenge in treatment and outcomes vary from subtype to another. Aim of The Work: Assessment of the outcome of R/R NHL in Egyptian patients receiving different salvage regimens. Patients and Methods: We conducted a retrospective cohort study on 55 patients with R/R NHL, undergoing salvage therapy and by following their records, the 3 year PFS and 3 year OS was measured against several parameters. Results: Our study showed that mean age of R/R NHL patients was 42 years, with male predominance (56.4%). Most patients had diffuse large B cell lymphoma (DLBCL) (74.5%). Most patients received the salvage regimen GDP (58.2%). 33 patients underwent autologous stem cell transplantation (ASCT), most of ASCT cases were uncomplicated (60.6%). The 3 year PFS was 62.3% and the 3 year OS was 52.7%. PFS and OS were affected by ASCT, and OS was impacted by the occurrence of ASCT complications and day of engraftment. Conclusion: In conclusion, there was no impact of salvage regimen or subtype of NHL on PFS and OS. ASCT results in better 3 year PFS and OS. | ||||
| Keywords | ||||
| Keywords: non-hodgkin lymphoma; relapsed/refractory; ASCT; HSCT | ||||
|
Statistics Article View: 53 |
||||
