Efficacy of Progestin Primed Ovarian Stimulation versus GnRH Antagonist Protocols in Clomiphene Resistant PCOS Undergoing ICSI Cycles. Randomized Controlled Trial (RCT) aa | ||||
| Minia Journal of Medical Research | ||||
| Articles in Press, Accepted Manuscript, Available Online from 12 March 2024 | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/mjmr.2024.259141.1586 | ||||
 View on SCiNiTO | ||||
| Authors | ||||
Mohamed Salah Abdel Hameed1; Manar Abdelhalim Elsayed Amin  2; Reham Refaat Taha3; Ayman Nady Abdel Megeed4
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| 1Department of obstetrics & Gynecology, Faculty of Medicine, Minia University, Egypt | ||||
| 2Obstetrics and gynecology Surgery, Faculty of medicine, Minya University. | ||||
| 3Department of Obstetrics and Gynecology, Faculty of medicine, Minya university, Egypt | ||||
| 4Department of Obstetrics and Gynecology, Faculty of Medicine, Minya University, Egypt. | ||||
| Abstract | ||||
| Background: Polycystic ovary syndrome (PCOS) is one of the endocrine disorders and anovulatory cycles of reproductive age women, it represents 70% of anovulation. Recent study has demonstrated that, the continuous administration of progestin showed a comparable pregnancy outcome compared to the conventional protocols such as short and GnRH antagonist protocols in infertile and poor responder patients with normal ovarian reserve. Aims and Objectives: This a Prospective Randomized Control Study Aimed to Evaluate the Efficacy of Progestin - Primed Ovarian Stimulation Versus GnRH - Antagonist in Patients with Clomiphene resistant PCOS Undergoing ICSI Cycles on Clinical Pregnancy Rate and Premature LH Surge. Patients and Methods: This study was conducted at one of the Privide IVF/ICSI center at Minia Govenate. The study was performed on a total of 100 infertile patients complaining of clomiphene-resistant or clomiphene failed PCOS underging ICSI cycles. All Patients were divided randomelly into two groups; group I who recieved (Progestin – Primed ovarian stimulation protocol), group II who recieved (GnRH – antagonist). Results: There was no significant differences between the two studied groups regarding the demographic characteristics basal hormonal levels (FSH,LH, Prolactin, TSH, and AMH), and incidence of multiple pregnancies, however there is statistically significant differences between the two studied groups in the median of MII, Fertilization rate, Pregnancy rate, Premature LH surge, mild and moderate OHSS, abortion rate and Cost effectiveness. Conclusion: Use of Progestin – Primed ovarian stimulation is safe , effective less cost, less complications with better reproductive outcomes compared to GnRH – antagonist Protocol | ||||
| Keywords | ||||
| Clomiphene - Failed or Resistant, PCOS, Progestin, GnRH – antagonist | ||||
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