Prediction Of Thromboembolic Stroke in Non-Valvular Atrial Fibrillation Patients With Low CHA2DS2-VASc Score
Elkot, M., Farag, E., Shams Eldeen, M., Abomandour, H. (2024). Prediction Of Thromboembolic Stroke in Non-Valvular Atrial Fibrillation Patients With Low CHA2DS2-VASc Score. EKB Journal Management System, 30(1.3), 139-148. doi: 10.21608/zumj.2024.274151.3224
Moataz A. Elkot; ELsayed M Farag; Mostafa Mahmoud Mohamed Shams Eldeen; Hala Gouda Abomandour. "Prediction Of Thromboembolic Stroke in Non-Valvular Atrial Fibrillation Patients With Low CHA2DS2-VASc Score". EKB Journal Management System, 30, 1.3, 2024, 139-148. doi: 10.21608/zumj.2024.274151.3224
Elkot, M., Farag, E., Shams Eldeen, M., Abomandour, H. (2024). 'Prediction Of Thromboembolic Stroke in Non-Valvular Atrial Fibrillation Patients With Low CHA2DS2-VASc Score', EKB Journal Management System, 30(1.3), pp. 139-148. doi: 10.21608/zumj.2024.274151.3224
Elkot, M., Farag, E., Shams Eldeen, M., Abomandour, H. Prediction Of Thromboembolic Stroke in Non-Valvular Atrial Fibrillation Patients With Low CHA2DS2-VASc Score. EKB Journal Management System, 2024; 30(1.3): 139-148. doi: 10.21608/zumj.2024.274151.3224

Prediction Of Thromboembolic Stroke in Non-Valvular Atrial Fibrillation Patients With Low CHA2DS2-VASc Score

Zagazig University Medical Journal
Article 17, Volume 30, Issue 1.3, March and April 2024, Page 139-148  XML PDF (1.13 MB)
Document Type: Original Article
DOI: 10.21608/zumj.2024.274151.3224
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Authors
Moataz A. Elkot email 1; ELsayed M Farag2; Mostafa Mahmoud Mohamed Shams Eldeen3; Hala Gouda Abomandour4
1Lecturer of cardiology faculty of medicine zagazig university
2cardiology department , faculty of medicine , zagazig university
3MBBCH, Cardiovascular Department, Nasser institute for research and treatment, Cairo,Egypt
4A. professor
Abstract
Background:Clinical research revealed that thromboembolic events are still a possibility for AF patients with low CHA2DS2-VASc scores

Aim:To assess the ability of certain echocardiographic parameters and laboratory biomarkers to predict thromboembolic events in AF patients with low CHA2DS2-VASc score

Patients and methods: This is a Case-control study at Cardiology Department, Zagazig University Hospitals and Nasser Institute for Research and Treatment ,was conducted on 159 patients: group 1 included 53 non valvular AF patients having low CHA2DS2-VASc score with Acute Ischemic Stroke (AIS), group 2 included 53 non valvular AF patients having low CHA2DS2-VASc score but without AIS and group 3 included 53 controls without AF or AIS. All groups were investigated by certain echocardiography parameters including left atrial emptying fraction(LAEF) , left atrial volume index (LAVI) , left atrial appendage flow velocity(LAA FV) , mitral annular velocity (E′) and E/e′ ratio , also they were investigated by some laboratory markers including platelet count , red cell distribution width(RDW), platelet distribution width(PDW) , creatinine level , D-dimer level and troponin I.

Results:Results: The Receiver Operating Characteristic (ROC) curve analysis showed that several echocardiographic parameters had significant predictive value for stroke ,these parameters were LAVI , LAeF, E/e' ratios, and LAAFV.Also the ROC curve analysis showed that PDW, D-dimer, and troponin had significant predictive value . A novel stroke risk scoring model was developed

Conclusion :The novel stroke risk score model may enhance prediction of LAA thrombus in non valvular AF patients with low CHADS-VASc score (0 in male,1 in female)
Keywords
Left Atrial Appendage Thrombus; Novel Risk Score; Acute Ischemic Stroke
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