Novel Chitosan Nanoparticles based 1,2,3-triazole moieties as potent drugs against multi-drug resistant bacteria
Mohamed, H., Elwakil, B., Hagar, M., Aouad, M., Rezki, N., Olama, Z., El Kilany, Y., Zakaria, M. (2024). Novel Chitosan Nanoparticles based 1,2,3-triazole moieties as potent drugs against multi-drug resistant bacteria. EKB Journal Management System, (), 28-33. doi: 10.21608/ajst.2024.257728.1024
Heba Mohamed; Bassma Elwakil; Mohamed Hagar; Mohamed Aouad; Nadjet Rezki; Zakia Olama; Yeldez El Kilany; Mohamed Zakaria. "Novel Chitosan Nanoparticles based 1,2,3-triazole moieties as potent drugs against multi-drug resistant bacteria". EKB Journal Management System, , , 2024, 28-33. doi: 10.21608/ajst.2024.257728.1024
Mohamed, H., Elwakil, B., Hagar, M., Aouad, M., Rezki, N., Olama, Z., El Kilany, Y., Zakaria, M. (2024). 'Novel Chitosan Nanoparticles based 1,2,3-triazole moieties as potent drugs against multi-drug resistant bacteria', EKB Journal Management System, (), pp. 28-33. doi: 10.21608/ajst.2024.257728.1024
Mohamed, H., Elwakil, B., Hagar, M., Aouad, M., Rezki, N., Olama, Z., El Kilany, Y., Zakaria, M. Novel Chitosan Nanoparticles based 1,2,3-triazole moieties as potent drugs against multi-drug resistant bacteria. EKB Journal Management System, 2024; (): 28-33. doi: 10.21608/ajst.2024.257728.1024

Novel Chitosan Nanoparticles based 1,2,3-triazole moieties as potent drugs against multi-drug resistant bacteria

Alexandria Journal of Science and Technology
Articles in Press, Accepted Manuscript, Available Online from 13 March 2024  XML PDF (2.01 MB)
Document Type: Original Article
DOI: 10.21608/ajst.2024.257728.1024
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Authors
Heba Mohamed1; Bassma Elwakil email orcid 2; Mohamed Hagar3; Mohamed Aouad4; Nadjet Rezki4; Zakia Olama5; Yeldez El Kilany3; Mohamed Zakaria3
1Chemistry department, Faculty of Science, Alexandria University
2Pharos University in Alexandria
3Department of Chemistry, Faculty of Science, Alexandria University, Alexandria 21568, Egypt
4Department of Chemistry, Faculty of Science, Taibah University, Al-Madinah Al-Munawarah 30002, Saudi Arabia
5Department of Botany & Microbiology, Faculty of Science, Alexandria University, Alexandria 21568, Egypt
Abstract
Drug resistance is a major global problem leading to higher morbidity and mortality rates especially among hospitalized patients. Hence in the present study, 1,2,3-Triazole-acetophnone molecular conjugates 3a-c were resynthesized and then used in nanoformulated composites (3a-cCNPs) using chitosan as a matrix to give nano compounds of particle size ranging from 20 to 40 nm. Antimicrobial activity of the synthesized compounds and the nanoformulated analogues against multi-drug resistant microbes revealed that 3bCNPs was the most potent candidate due to its high efficiency against multi-drug resistant (MDR) microbes that reached complete microbial cells eradication after 4 hours. The synthesized nanoparticles were fully char-acterized through TEM, FTIR and XRD which proved the homogeneity of the synthesized nanoformula with particle size ranged between 20 to 40 nm. The present findings discovered novel antimicrobial activities that may have therapeutic potentials. This discovery may lead to an assumption that the tested compounds can be used as candidates in biomedical applications against drug resistant microbes.
Keywords
Chitosan-1,2,3-Triazoles Nanoformulae; MDR bacteria; Characterization
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