Role of miR-155 expression in acute myeloid leukemia and correlation with nucleophosmin 1 (NPM1) mutations modyfied
Hegazy, L., Soliman, N., Nasr, A., Abd El Dayem, O., Nassar, H., Embaby, R. (2024). Role of miR-155 expression in acute myeloid leukemia and correlation with nucleophosmin 1 (NPM1) mutations modyfied. EKB Journal Management System, (), -. doi: 10.21608/arcmed.2024.270038.1045
Laila A Hegazy; Nohair Soliman; Aml S Nasr; Omnia Y Abd El Dayem; Hanan R Nassar; Reem M Embaby. "Role of miR-155 expression in acute myeloid leukemia and correlation with nucleophosmin 1 (NPM1) mutations modyfied". EKB Journal Management System, , , 2024, -. doi: 10.21608/arcmed.2024.270038.1045
Hegazy, L., Soliman, N., Nasr, A., Abd El Dayem, O., Nassar, H., Embaby, R. (2024). 'Role of miR-155 expression in acute myeloid leukemia and correlation with nucleophosmin 1 (NPM1) mutations modyfied', EKB Journal Management System, (), pp. -. doi: 10.21608/arcmed.2024.270038.1045
Hegazy, L., Soliman, N., Nasr, A., Abd El Dayem, O., Nassar, H., Embaby, R. Role of miR-155 expression in acute myeloid leukemia and correlation with nucleophosmin 1 (NPM1) mutations modyfied. EKB Journal Management System, 2024; (): -. doi: 10.21608/arcmed.2024.270038.1045

Role of miR-155 expression in acute myeloid leukemia and correlation with nucleophosmin 1 (NPM1) mutations modyfied

ARCADEs of MEDICINE
Articles in Press, Accepted Manuscript, Available Online from 16 March 2024  XML
Document Type: Original Research
DOI: 10.21608/arcmed.2024.270038.1045
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Authors
Laila A Hegazy1; Nohair Soliman1; Aml S Nasr email 2; Omnia Y Abd El Dayem1; Hanan R Nassar3; Reem M Embaby4
1Department of Clinical and Chemical Pathology, Faculty of Medicine, Cairo University, Egypt.
2Kasr Al Aini School of medicine,Cairo,Egypt
3Department of medical oncology , National cancer institute , Cairo University, Egypt.
4National nutrition institute
Abstract
Background: Acute myeloid leukemia (AML) is a highly heterogeneous disease marked by the inability of progenitor cells in the bone marrow to differentiate terminally from developing to mature blood cells . Furthermore, microRNAs (miRNAs) are short, non-coding RNAs that regulate multiple gene expressions that regulate hematopoietic stem/progenitor cell commitment and differentiation.

Methods: The present study involved 40 patients newly diagnosed with AML in addition to 40 matched controls. A quantitative reverse transcription real-time PCR (qRT-PCR) assay was performed to quantify miR-155. The NPM1 mutations in a new cohort of Egyptian AML patients were assessed using RT-PCR assays. The aim was to examine the correlation between these mutations and microRNAs, as well as to determine their expression in relation to demographic, clinical, and laboratory data.

Results: For Mir-155, there was were a statistically substantial differences between the mean CT values of patients and controls. NPM1 results exhibited marked differences between controls and patients.

Conclusion: In conclusion, the value of 155 did not accurately predict cases of AML. Additionally, no correlation was observed between NPM1 and miR-155.
Keywords
AML; miR-155; qRT-PCR; NMP
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