Effect of Obesity on Awakening Time after Isoflurane/Sevoflurane Inhalation Anesthesia in Dogs | ||||
| Journal of Applied Veterinary Sciences | ||||
| Article 11, Volume 9, Issue 2, April 2024, Page 106-110 PDF (572.43 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/javs.2024.266563.1311 | ||||
 View on SCiNiTO | ||||
| Authors | ||||
MASAO ARISATO1; SHOZO OKANO  2
| ||||
| 1Hyogo Pet Medical Center, 3-1-5 Tachibana-cho, Amagasaki-city, Hyogo, Japan | ||||
| 2Laboratory of Small Animal Surgery 2, School of Veterinary Medicine, Kitasato University, 35-1 Higashi 23 bancho, Towada, Aomori, Japan | ||||
| Abstract | ||||
| To elucidate the relationship between obesity, awakening time, and anesthesia in dogs, we conducted a comparative analysis of the awakening time following isoflurane and sevoflurane anesthesia in both standard-weight and obese groups. Six female beagle dogs within the standard weight range underwent 1-hour inhalation anesthesia with either isoflurane or sevoflurane. We recorded the time of extubation, head lift, and standing. Additionally, a parallel experiment was conducted on the same test animals after inducing obesity through nutritional management, with criteria for obesity defined as a body conditioning score of 4 or higher and a body fat percentage of 30% or higher. Under isoflurane anesthesia, we observed a tendency for a longer awakening time in the obese group compared to the standard weight group. However, this trend was not evident with sevoflurane anesthesia. Furthermore, when comparing awakening time with both anesthetics, no significant difference was found between the standard weight groups. In contrast, within the obese group, awakening time was significantly prolonged with isoflurane anesthesia compared to sevoflurane anesthesia. These results confirm that obesity contributes to delay awakening in dogs. Additionally, in the anesthesia management of obese dogs, the use of sevoflurane is anticipated to reduce awakening time compared to isoflurane. | ||||
| Keywords | ||||
| Awakening time; Dog; Isoflurane; Obese; Sevoflurane | ||||
| References | ||||
|
ADAMS, J. P., and MURPHY, P. G., 2000. Obesity in anesthesia and intensive care. British Journal of Anesthesia, 85:91-108. https://doi.org/10.1093/bja/85.1.91
AGOLIATI, A., DEXTER, F., LOK, J., MASURSKY, D., SARWAR, M. F., STUART, S. B., BAYMAN, E. O., and EPSTEIN, R. H., 2010. Meta-analysis of average and variability of time to extubation comparing isoflurane with desflurane or isoflurane with sevoflurane. Anesthesia and Analgesia, 110:1433-1439. https://doi.org/10.1213/ane.0b013e3181d58052
BEHNE, M., WILKE, H., and LISCHKE, V., 1999. Recovery and pharmacokinetic parameters of desflurane, sevoflurane, and isoflurane in patients undergoing urologic procedures. Journal of Clinical Anesthesia, 11:460-465. https://doi.org/10.1016/j.jclinane.2023.111210
CASATI, A., and PUTZU, M., 2005. Anesthesia in the obese patient:pharmacokinetic considerations. Journal of Clinical Anesthesia, 17:134-145. https://doi.org/10.1016/j.jclinane.2004.01.009
DEVITO, F. C., PATRICIO, G. C. F., FLOR, P. B., VENDRAMINI, T. H. A., AMARAL, A. R., BRUNETTO, K. P. M. A., and CORTOPASSI, S. R. G., 2020. Comparative study of anesthesia induction in obese dogs using propofol dosages based on lean body weight or total body weight. Veterinary and Animal Science, 10:100131. https://doi.org/10.1016/j.vas.2020.100131
EGER, Ⅱ. E. Ⅰ. 2004. Characteristics of anesthetic agents used for induction and maintenance of general anesthesia. American Journal of Health-System Pharmacy, 61:S3-10. https://doi.org/10.1093/ajhp/61.suppl_4.S3
EGER, Ⅱ. E. Ⅰ., and SAIDMAN, L. J., 2005. Illustrations of inhaled anesthetic uptake,including intertissue diffusion to and from fat. Anesthesia and Analgesia, 100:1020-1033. https://doi.org/10.1213/01.ane.0000146961.70058.a1
GROEBEN, H., MEIER, S., TANKERSLEY, C. G., MITZNER, W., and BROWN, H., 2004. Influence of volatile anesthetics on hypercapnoeic ventilator responses in mice with blunted respiratory drive. British Journal of Anesthesia, 92:697-703. https://doi.org/10.1093/bja/aeh124
LAFLAMME D.P. 2006. Understanding and managing obesity in dogs and cats. Veterinary Clinics of North America: Small Animal Practice, 36:1283-1295. https://doi.org/10.1016/j.cvsm.2006.08.005
LEBUFFE, G., ANDRIEU, G., WIERRE, F., GORSKI, K., SANDERS, V., CHALONS, N., and VALLET, B., 2010. Anesthesia in the obese. Journal of Visceral Surgery, 147S, e11-e19. https://doi.org/10.1016/j.jviscsurg.2010.08.013
LEMMENS, H. J., SAIDMAN, L. J., EGER, E. I. Ⅱ., and LASTER, M. J., 2008. Obesity modestly affects inhaled anesthetic kinetics in humans. Anesthesia and Analgesia, 107:1864-1870. https://doi.org/10.1213/ane.0b013e3181888127
LOVE, L., and CLINE, M. G., 2015. Perioperative physiology and pharmacology in the obese small animal patient. Veterinary Anesthesia and Analgesia, 42:119-132. https://doi.org/10.1111/vaa.12219
PATEL, S. S., and GOA, K. L., 1996. Sevoflurane:a review of its pharmacodynamic and pharmacokinetic properties and its clinical use in general anesthesia. Drugs, 51:658-700. https://doi.org/10.2165/00003495-199651040-00009
PELOSI, P., CROCI, M., RAVAGNAN, I., VICARDI, P., and GATTINONI, L., 1996. Total respiratory system, lung, and chest wall mechanics in sedated-paralyzed postoperative morbidly obese patients. Chest, 109:144-151. https://doi.org/10.1378/chest.109.1.144
ROBINSON, B. J., UHRICH, T. D., and EBERT, T. J., 1999. A review of recovery from sevoflurane anesthesia: comparisons with isoflurane and propofol including meta-analysis. Acta Anaesthesiologica Scandinavica, 43:185-190. https://doi.org/10.1034/j.1399-6576.1999.430211.x
SAKAI, E. M, CONNOLLY, L. A., and KLAUCK, J. A., 2005. Inhalation anesthesiology and volatile liquid anesthetics: focus on isoflurane, desflurane, and sevoflurane. Pharmacotherapy, 25:1773-88. https://doi.org/10.1592/phco.2005.25.12.1773
STEFFEY E.P., MAMA K.R., and BROSNAN R.J., 2015. Inhalation Anesthetics. In: Veterinary Anesthesia and Analgesia, Fifth Ed. Wiley Blackwell, Iowa, USA, pp.297-331.
STOELTING, R. K. and MILLER, R. D., 2007. Section Ⅱ Pharmacology. In: Basic of Anesthesia, 5th. Ed. Elsevier, Philadelphia, USA, pp.37-157.
TOLL, P. W., YAMKA, R. M., SCHOENHERR, W. D., and HAND, M. S., 2010. Obesity. In: Small Animal Clinical Nutrition, 5th Ed. Mark Morris Institute, Topeka, USA, pp.501-542.
TROPF, M., NELSON, O. L., LEE, P. M., and WENG, H. Y., 2017. Cardiac and metabolic variables in obese dogs. Journal of Veterinary Internal Medicine, 31:1000–1007. https://doi.org/10.1111/jvim.14775 | ||||
|
Statistics Article View: 125 PDF Download: 51 |
||||
