Analgesic and Anti-inflammatory Effects of Montelukast in Chicks
Albadrany, Y., naser, A., Mousa, Y. (2024). Analgesic and Anti-inflammatory Effects of Montelukast in Chicks. EKB Journal Management System, 55(7), 1933-1938. doi: 10.21608/ejvs.2024.266227.1810
Yasser Albadrany; ahmed naser; Yaareb J. Mousa. "Analgesic and Anti-inflammatory Effects of Montelukast in Chicks". EKB Journal Management System, 55, 7, 2024, 1933-1938. doi: 10.21608/ejvs.2024.266227.1810
Albadrany, Y., naser, A., Mousa, Y. (2024). 'Analgesic and Anti-inflammatory Effects of Montelukast in Chicks', EKB Journal Management System, 55(7), pp. 1933-1938. doi: 10.21608/ejvs.2024.266227.1810
Albadrany, Y., naser, A., Mousa, Y. Analgesic and Anti-inflammatory Effects of Montelukast in Chicks. EKB Journal Management System, 2024; 55(7): 1933-1938. doi: 10.21608/ejvs.2024.266227.1810

Analgesic and Anti-inflammatory Effects of Montelukast in Chicks

Egyptian Journal of Veterinary Sciences
Volume 55, Issue 7, November and December 2024, Page 1933-1938  XML PDF (963.56 K)
Document Type: Original Article
DOI: 10.21608/ejvs.2024.266227.1810
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Authors
Yasser Albadrany email orcid 1; ahmed naserorcid 2; Yaareb J. Mousaorcid 3
1Department of Physiology, Biochemistry, and Pharmacology, College of Veterinary Medicine, University of Mosul, Mosul, IRAQ
2Department of physiology, biochemistry, and pharmacology, College of Veterinary Medicine, University of Mosul, Mosul, Iraq
3Department of Physiology, Biochemistry, and Pharmacology, College of Veterinary Medicine, University of Mosul, Mosul-Iraq
Abstract
The goal of the study was to assess the analgesic and anti-inflammatory properties of montelukast in chicks. Methods: The oral median analgesic effective dose (ED50) of montelukast was determined by the up-and-down method.  An electrical stimulator was used to determine the analgesia of montelukast over time. Formalin test was used to determine the analgesic and anti-inflammatory activities of montelukast. Results: oral median analgesic effective dose (ED50) of montelukast was 9.23 mg/kg. Montelukast (18 and 36 mg/kg) had significant analgesic activity over time compared with a control group, and the peak of analgesia of montelukast was observed later one hour of treatment. Montelukast showed significant analgesic and anti-inflammatory activities in the formalin test, represented by a significant increase in the commencement of lifting the right foot, a decrease in the number of lifting the right foot, and significant a decrease in the thickness of the paw in comparison to control group. Conclusion: Montelukast possesses noteworthy effects of eliminating pain and inflammation in chicks.
Keywords
Montelukast; Analgesic; Anti-inflammatory; Chicks
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