MIGHT FENUGREEK SEED EXTRACT BE A PROPHYLACTIC THERAPY FROM OSTEOPOROSIS? | ||||
| Egyptian Journal of Orthopedic Research | ||||
| Article 1, Volume 4, Issue 2, December 2023, Page 41-44 PDF (194.48 K) | ||||
| Document Type: Review articles: systemic review of different literatures. | ||||
| DOI: 10.21608/ejor.2023.346400 | ||||
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| Authors | ||||
| Mohamed E Abdel-Wanis1; Mansour Mohammed Aldhilan2 | ||||
| 1Orthopedic Department, Ar Rass General Hospital, Kingdom of Saudia Arabia. Orthopedic Department, Sohag Faculty of Medicine, Sohag, Egypt | ||||
| 2Orthopedic Department, Ar Rass General Hospital, Kingdom of Saudia Arabia | ||||
| Abstract | ||||
| Osteoporosis is a systemic bone disease characterized by reduced bone mass and the deterioration of bone microarchitecture leading to bone fragility and an increased risk of fractures. Fenugreek regulates osteogenic markers and upregulates osteoblast differentiation by stimulating extracellular calcium concentrations as well as osteoblast differentiation. Experimental studies have shown that it increases osteocalcin and bone morphogenic protein-2 (BMP-2) levels in treated cells. Fenugreek causes DNA damage of osteoclasts. Also, fenugreek steroidal saponins hinder osteoclastogenic bone resorption. Trigonelline, a known constituent of fenugreek seeds, showed significant improvement and prevent the progression of osteoporosis We conclude that fenugreek seed extract might be of benefit for prophylaxis from osteoporosis. However, a well-planned randomized controlled trial is needed to have level I evidence of its efficacy | ||||
| Keywords | ||||
| Osteoporosis; Fenugreek; Osteoclast; Osteoblast; bone resorption | ||||
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