Estimation of the Efficacy of Oral Administration of Egyptian Artemisia herba-alba Extract in Combating Thyroid Dysfunction in Diabetic Male Rats
El-Sawi, N., El-Hady, O., El-Aref, A., Hefny Gad, M. (2024). Estimation of the Efficacy of Oral Administration of Egyptian Artemisia herba-alba Extract in Combating Thyroid Dysfunction in Diabetic Male Rats. EKB Journal Management System, 9(3), 234-240. doi: 10.21608/sjsci.2024.257683.1166
Nagwa Mohamed El-Sawi; Omer M. El-Hady; Amira Hmady El-Aref; Mahmoud Hefny Gad. "Estimation of the Efficacy of Oral Administration of Egyptian Artemisia herba-alba Extract in Combating Thyroid Dysfunction in Diabetic Male Rats". EKB Journal Management System, 9, 3, 2024, 234-240. doi: 10.21608/sjsci.2024.257683.1166
El-Sawi, N., El-Hady, O., El-Aref, A., Hefny Gad, M. (2024). 'Estimation of the Efficacy of Oral Administration of Egyptian Artemisia herba-alba Extract in Combating Thyroid Dysfunction in Diabetic Male Rats', EKB Journal Management System, 9(3), pp. 234-240. doi: 10.21608/sjsci.2024.257683.1166
El-Sawi, N., El-Hady, O., El-Aref, A., Hefny Gad, M. Estimation of the Efficacy of Oral Administration of Egyptian Artemisia herba-alba Extract in Combating Thyroid Dysfunction in Diabetic Male Rats. EKB Journal Management System, 2024; 9(3): 234-240. doi: 10.21608/sjsci.2024.257683.1166

Estimation of the Efficacy of Oral Administration of Egyptian Artemisia herba-alba Extract in Combating Thyroid Dysfunction in Diabetic Male Rats

Sohag Journal of Sciences
Volume 9, Issue 3, September 2024, Page 234-240  XML PDF (412.2 K)
Document Type: Regular Articles
DOI: 10.21608/sjsci.2024.257683.1166
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Authors
Nagwa Mohamed El-Sawi1; Omer M. El-Hady1; Amira Hmady El-Aref1; Mahmoud Hefny Gad email orcid 2
1Department of Chemistry, Faculty of Science, Sohag University, Sohag, 82524, Egypt.
2Medicinal and Aromatic Plants Research Department, Horticulture Institute, Agricultural Research Center, Dokki, Giza, 12619, Egypt.
Abstract
Herbal treatments occupy a wide range of medical attempts to treat diabetes, and among these is Artemisia herba-alba (AHA) has impressive botanical vegetation in Egypt. For a long time, Artemisia herba-alba has been used in traditional medicine as a tonic, diuretic, anthelmintic, and depurative as a result of the occurrence of numerous phytochemical components, such as phenols and flavonoids. Thus, the current study aims to estimate of thyroid efficacy of oral administration of Egyptian AHA. For this purpose, 45 albino rats (male) were distributed into three groups (fifteen rats per group), group 1; control group, group 2; diabetic, group 3; protective group. Subsequently, thyroid-stimulating hormone (TSH), triiodothyronine (T3), and thyroxin-binding globulin (T4) were investigated. Moreover, total flavonoid content (TFC) and total phenolic content (TPC), qualitative screening analyses, and Gas chromatography-mass spectroscopy (GC-MS) were performed. Biochemical investigations, the results showed a slight improvement of T3 in group 3 compared to group 2, while TSH and T4 of group 3 showed an improvement compared to group 2. Furthermore, the qualitative analyses of AHA extract showed the occurrence of flavonoids, alkaloids, reducing sugar, saponins, and tannins. However, the quantitative analyses revealed TPC and TFC values to be 444.15, 8.18, mg GA/g DW, and mg QE/g DW, respectively. GC-MS exhibited the existence of varied bioactive compounds, while the main chemical constituents were Undecane (5.86%), Hexane, 2,5-dimethoxy-2,5-dimethyl (7.32%), trans-Arbusculone (8.54%), (2β,3β,5β)- 2,3,14-trihydroxy-7-ene-6,17-dione, Androst-(8.81%), 4β-Methylandrostane2,3-diol-1,17-dione (5.78%). In conclusion, our results suggested a potent protective effect of Artemisia herba-alba, which may be considered as anti-inflammatory agent.
Keywords
Artemisia herba-alba; diabetes mellitus; thyroid; qualitative and quantitative analyses; GC-MS
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