A Green Method for the Determination of Mebeverine in Its Pharmaceutical Products and Human Serum Based On Diatom Modified Carbon Paste Electrode Using Square Wave Adsorptive Anodic Stripping Voltammetry (SW-AdASV) | ||||
| The International Conference on Chemical and Environmental Engineering | ||||
| Article 1, Volume 9, 9th International Conference on Chemical & Environmental Engineering, April 2018, Page 2-20 PDF (1.4 MB) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/iccee.2018.34645 | ||||
 View on SCiNiTO | ||||
| Authors | ||||
| Fared M. El-badawy1, 2; Hanaa S. El-Desoky3; Mohamed M. Ghoneim3 | ||||
| 1Analytical and Electrochemistry Research Unit, Department of Chemistry, Faculty of Science, Tanta University, 31527 Tanta, Egypt+ | ||||
| 2Egyptian Ministry of Industry, Chemistry Administration, Cairo, Egypt. | ||||
| 3Analytical and Electrochemistry Research Unit, Department of Chemistry, Faculty of Science, Tanta University, 31527 Tanta, Egypt. | ||||
| Abstract | ||||
| Abstract The first use of a green method of analysis using diatom for trace determination of mebeverine in its pharmaceutical formulation and human serum based on its great properties such as high surface area, hydrophilicity, and adsorption. in addition to diatom requires no chemical modification. Characterization of Diatom using FTIR showed bands corresponding to AlMgOH, Si-O-Al, SiOH, and OH, while XRD showed that diatom is amorphous containing silica of quartz crystal shape, SEM revealed that diatom has porous surface. Cyclic Voltammetry of the modified electrode revealed that the modified electrode has higher surface area and greater adsorption. Mebeverine hydrochloride (MV.HCl) was determined based on 5% diatom modified carbon paste electrode 5% (w/w)DA/CPE as a sensor with LOD and LOQ of 1.80×10−9 and 6.00×10−9 respectively. Then, the modified electrode was successfully applied for the trace determination of MV.HCl in different pharmaceutical preparations; “Coloverin A”, “Colona” and “Colofac” tablets without interferences from excipients and co-formulated drugs. The achieved detection limit in human serum was 8.0×10−9 M. The described adsorptive anodic stripping voltammetric method is reliable, simple, and sensitive enough for assay of MV.HCl in real plasma samples, pharmacokinetic studies, quality control and assurance of the drug in industry and in clinical laboratories. | ||||
| Keywords | ||||
| Square wave anodic stripping voltammetry; SW-AdASV; diatom; Mebeverine | ||||
|
Statistics Article View: 419 PDF Download: 467 |
||||
