Protective Effect of Nano-Moringa Oleifera leaves Extract and/or Low Doses of γ- Irradiation on Acute Pancreatitis Model Induced in Rats.
farghly, G., Hanafy, N., gewily, D., El-tonsy, M., Farid, N. (2023). Protective Effect of Nano-Moringa Oleifera leaves Extract and/or Low Doses of γ- Irradiation on Acute Pancreatitis Model Induced in Rats.. EKB Journal Management System, 2(2), 215-224. doi: 10.21608/ijtar.2023.205193.1052
Gehad Mohammed farghly; Neamat Hanafy; Doaa gewily; mona El-tonsy; Nahed Farid. "Protective Effect of Nano-Moringa Oleifera leaves Extract and/or Low Doses of γ- Irradiation on Acute Pancreatitis Model Induced in Rats.". EKB Journal Management System, 2, 2, 2023, 215-224. doi: 10.21608/ijtar.2023.205193.1052
farghly, G., Hanafy, N., gewily, D., El-tonsy, M., Farid, N. (2023). 'Protective Effect of Nano-Moringa Oleifera leaves Extract and/or Low Doses of γ- Irradiation on Acute Pancreatitis Model Induced in Rats.', EKB Journal Management System, 2(2), pp. 215-224. doi: 10.21608/ijtar.2023.205193.1052
farghly, G., Hanafy, N., gewily, D., El-tonsy, M., Farid, N. Protective Effect of Nano-Moringa Oleifera leaves Extract and/or Low Doses of γ- Irradiation on Acute Pancreatitis Model Induced in Rats.. EKB Journal Management System, 2023; 2(2): 215-224. doi: 10.21608/ijtar.2023.205193.1052

Protective Effect of Nano-Moringa Oleifera leaves Extract and/or Low Doses of γ- Irradiation on Acute Pancreatitis Model Induced in Rats.

International Journal of Theoretical and Applied Research
Article 7, Volume 2, Issue 2, December 2023, Page 215-224  XML PDF (754.29 K)
Document Type: Original Article
DOI: 10.21608/ijtar.2023.205193.1052
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Authors
Gehad Mohammed farghly email 1; Neamat Hanafy2; Doaa gewily1; mona El-tonsy3; Nahed Farid4
1Zoology Department, Faculty of Science AL-Azhar University (Girls)
2National Center for Radiation Research and Technology, Atomic Energy Authority
3Zoology Department, Faculty of Science, Al-Azhar University, Egypt
4Zoology Department, Faculty of Science Al-Azhar University (Girls
Abstract
Advances in the field of nanotechnology and its applications to medicine and pharmaceuticals in phyto medicines are thought to have advantages over traditional medications and are regaining interest in current research. Yet, some studies have found that modest doses of -irradiation may activate the immune system. In this study the impact of nano-Moringa oleifera (MO) leaves extract and/or low dosages of - irradiation on acute pancreatitis models produced in rats was studied. There were five groups of albino rats, each with ten rats. After one week of therapy, all animals were slaughtered. Acute pancreatitis resulted in a very substantial increase in lipase, amylase, Random Blood Sugar (RBS), and C-Reactive Protein (CRP) levels, as well as a considerable fall in insulin levels and Insulin growth factor 1. (IGF1). Histopathological examination of pancreatic tissue slices revealed a cluster of immune cells (lymphoid aggregation), haemorrhage, and necrotic acini. A significant reduction was observed after treatment with low doses of -irradiation and nano-Moringa leaves extract, either alone or combined, as compared to the positive control group (PC). On the contrary hand, normal tissue structure (normal islets of Langerhans and normal acini) was observed. In conclusion, nano-Moringa oleifera leaves extract and/or low doses of γ- irradiation has a therapeutic effect on acute pancreatitis model induced in rats.
Keywords
nano- Moringa oleifera; Arg; Pancreatitis; IR
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