The crucial role of long non-coding RNAs in the pathogenesis, therapeutic response, and clinical implications of esophageal cancer
El-Husseiny, A., Ali, N., Fakhry, M. (2024). The crucial role of long non-coding RNAs in the pathogenesis, therapeutic response, and clinical implications of esophageal cancer. EKB Journal Management System, (), 1-21. doi: 10.21608/erurj.2024.228118.1067
Ahmed A. El-Husseiny; Nada S. Ali; Morkoss M. Fakhry. "The crucial role of long non-coding RNAs in the pathogenesis, therapeutic response, and clinical implications of esophageal cancer". EKB Journal Management System, , , 2024, 1-21. doi: 10.21608/erurj.2024.228118.1067
El-Husseiny, A., Ali, N., Fakhry, M. (2024). 'The crucial role of long non-coding RNAs in the pathogenesis, therapeutic response, and clinical implications of esophageal cancer', EKB Journal Management System, (), pp. 1-21. doi: 10.21608/erurj.2024.228118.1067
El-Husseiny, A., Ali, N., Fakhry, M. The crucial role of long non-coding RNAs in the pathogenesis, therapeutic response, and clinical implications of esophageal cancer. EKB Journal Management System, 2024; (): 1-21. doi: 10.21608/erurj.2024.228118.1067

The crucial role of long non-coding RNAs in the pathogenesis, therapeutic response, and clinical implications of esophageal cancer

ERU Research Journal
Articles in Press, Accepted Manuscript, Available Online from 20 March 2024  XML PDF (329.11 K)
Document Type: Review articles
DOI: 10.21608/erurj.2024.228118.1067
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Authors
Ahmed A. El-Husseiny email 1; Nada S. Ali2; Morkoss M. Fakhry2
1Department of Biochemistry, Faculty of Pharmacy, Egyptian Russian University, Badr City 11829, Cairo, Egypt/ Biochemistry and Molecular Biology Department, Faculty of Pharmacy (Boys), Al-Azhar University, Nasr City 11231, Cairo, Egypt.
2Department of Biochemistry, Faculty of Pharmacy, Egyptian Russian University, Badr City 11829, Cairo, Egypt
Abstract
Esophageal cancer (EC) is the 2nd fatal gastrointestinal tract malignancy and the sixth most predominant driver of cancer-associated mortality worldwide. Interestingly, long non-coding RNAs (lncRNAs) have a sequence of more than 200 base pairs and are regarded as one of the epigenetic elements. LncRNAs have been demonstrated to influence EC features comprising initiation, development, angiogenesis, invasion, and metastasis. Notably, lncRNAs could modulate the expression of several genes and chromatin architectures which are implicated in EC pathogenesis. Besides, numerous lncRNAs have a crucial role in the chemotherapeutic response of EC cells. Furthermore, lncRNAs are thought to be a promising biomarker in EC whose expression patterns can distinguish between EC subtypes and stages as well as predict cancer aggressiveness. Thus, the current review emphasizes the latest updates on the modulatory functions of lncRNAs in EC pathogenesis, their significance to the EC cells' therapeutic response, and their clinical efficacy as prognostic and diagnostic biomarkers.
Keywords
Esophageal cancer; LncRNAs; Chemotherapeutic resistance; Diagnosis; Prognosis
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