Preparation and in vitro Characterization of Chitosan Nanoparticles loaded with Ciprofloxacin Hydrochloride
A, K., S, R., A, H., I, K., M, A. (2018). Preparation and in vitro Characterization of Chitosan Nanoparticles loaded with Ciprofloxacin Hydrochloride. EKB Journal Management System, 9(9th International Conference on Chemical & Environmental Engineering), 217-231. doi: 10.21608/iccee.2018.34665
Kotb M A; Ramadan H S; Hazzah W A; Khedr Y I; Abd-Elaziz M M. "Preparation and in vitro Characterization of Chitosan Nanoparticles loaded with Ciprofloxacin Hydrochloride". EKB Journal Management System, 9, 9th International Conference on Chemical & Environmental Engineering, 2018, 217-231. doi: 10.21608/iccee.2018.34665
A, K., S, R., A, H., I, K., M, A. (2018). 'Preparation and in vitro Characterization of Chitosan Nanoparticles loaded with Ciprofloxacin Hydrochloride', EKB Journal Management System, 9(9th International Conference on Chemical & Environmental Engineering), pp. 217-231. doi: 10.21608/iccee.2018.34665
A, K., S, R., A, H., I, K., M, A. Preparation and in vitro Characterization of Chitosan Nanoparticles loaded with Ciprofloxacin Hydrochloride. EKB Journal Management System, 2018; 9(9th International Conference on Chemical & Environmental Engineering): 217-231. doi: 10.21608/iccee.2018.34665

Preparation and in vitro Characterization of Chitosan Nanoparticles loaded with Ciprofloxacin Hydrochloride

The International Conference on Chemical and Environmental Engineering
Article 12, Volume 9, 9th International Conference on Chemical & Environmental Engineering, April 2018, Page 217-231  XML PDF (1.48 MB)
Document Type: Original Article
DOI: 10.21608/iccee.2018.34665
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Authors
Kotb M A1; Ramadan H S1; Hazzah W A2; Khedr Y I3; Abd-Elaziz M M4
1Dept. of Medical- Biophysics, Medical Research Institute, Alexandria University.
2Dept. of Microbiology, High Institute of Public Health, Alexandria University.
3Dept. of Physics, Faculty of Science, Damanhur University, Egypt.
4in Medical- Biophysics, Medical Research Institute, Alexandria University.
Abstract
Abstract
Ciprofloxacin hydrochloride is a broad spectrum antibiotic, effective against various types of micro-organisms but its controlled release formulation is recommended due to its short biological half-life (4 hrs). It was the aim of the present work to prolong its release after administration. So, Ciprofloxacin HCl loaded Chitosan Nanoparticles were prepared by the ionic gelation method. Characterization and evaluation of the in vitro release of Chitosan Nanoparticles loaded with Ciprofloxacin hydrochloride were studied. The data of the study clearly demonstrated that, Ciprofloxacin HCl loaded Chitosan Nanoparticles were 60.175 ± 4.973 nm in size with almost 90.713 % Ciprofloxacin HCl encapsulation efficiency. The TEM micrographs showed that the Nanoparticles surface looked spherical or oval and Ciprofloxacin HCl incorporation increases size of Nanoparticles loaded with Ciprofloxacin HCl compared to the empty ones. In vitro release of Ciprofloxacin HCl from Ciprofloxacin HCl loaded CS Nanoparticles was determined in phosphate buffered saline (PBS, pH 7.4), and the data showed an initial burst release followed by slow sustained drug release rate (81.698 % within 24 hour ). These observations suggest that the Nanoparticles prepared by ionic gelation process without using harsh organic chemicals might be recommended as a controlled drug delivery systems to improve efficacy, reduce toxicity, and improve patient compliance.
Keywords
Ciprofloxacin HCl; Chitosan nanoparticles; Ionic gelation method
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