Novel In Situ Gel for Molnupiravir-Loaded Niosomes: Design, In Vitro Characterization and In Vivo Evaluation | ||||
| Egyptian Journal of Chemistry | ||||
| Articles in Press, Accepted Manuscript, Available Online from 21 March 2024 | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/ejchem.2024.267230.9279 | ||||
 View on SCiNiTO | ||||
| Authors | ||||
Hadeer A El Hashemy   1; Abeer Salama 2; Amira Rashad3
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| 1national research centre, pharmaceutical technology department | ||||
| 2pharmacology, NRC | ||||
| 3pharmaceutics and industrial pharmacy, heliopolis university | ||||
| Abstract | ||||
| Acute lung injury is a clinical disease that causes damage to the pulmonary capillary endothelium leading to a notable rate of morbidity. Clinical manifestations of SARS-CoV-2 infections vary; some persons remain asymptomatic, while others develop COVID-19, with mild to critical severity. Molnupiravir is an antiviral candidate with demonstrating efficacy against SARS-CoV-2. The present investigation aims at developing Molnupiravir thermosensitive in situ nasal gel for the treatment of acute lung and respiratory injuries with improved therapeutic efficacy. Niosome encapsulation efficiency, vesicle size, shape, and size distribution were investigated. The optimized niosomes, comprised of Span® 60 and cholesterol, displayed particle size of 92.215 ± 6 nm, zeta potential of -29.67 ± 0.22 mV and encapsulation efficiency of 95.36 ± 1.5%. The optimal nano-dispersion was incorporated into hydroxyethyl cellulose. The resulting gels showed pseudoplastic mucoadhesive appearance with a prolonged in vitro drug release pattern. Instillation of the Molnupiravir-loaded niosomal gel into rats’ nasal cavity ameliorated lung damage via a reduction of the cytokine storms induced by potassium dichromate (TNF-α / TGF-β). Molnupiravir-loaded niosomal gel elevated PI3K/ Akt signaling pathway which promoted cellular growth. Consequently, the invented nano-particulate gelling system may offer an appropriate carrier for better enhancement of serious respiratory disorders | ||||
| Keywords | ||||
| Keywords: Molnupiravir; Acute lung injuries; In situ nasal gel; Niosomes, potassium dichromate; PI3K/ Akt.&lrm | ||||
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