Effect of Diabetes Mellitus on Oxidative Stress and Inflammatory Markers in Parkinson&#039;s Adult Male Albino Rats

Mansour, Niera Mohamed sameh; Abdel-Hakim, Selim Mahmoud; Saad, Adel Hussein; Elbassuoni, Eman Abd Elmonem; Habib, Wagdy Nashaat

doi:10.21608/mjmr.2024.277030.1691

	Effect of Diabetes Mellitus on Oxidative Stress and Inflammatory Markers in Parkinson's Adult Male Albino Rats
Minia Journal of Medical Research
Articles in Press, Accepted Manuscript, Available Online from 24 March 2024
Document Type: Original Article
DOI: 10.21608/mjmr.2024.277030.1691
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Authors
Niera Mohamed sameh Mansour ¹; Selim Mahmoud Abdel-Hakim²; Adel Hussein Saad³; Eman Abd Elmonem Elbassuoni²; Wagdy Nashaat Habib³
¹Department of medical physiology, faculty of medicine, minia university, minia city, Egypt
²physiology department, faculty of medicine, Minia university
³Department of Medical Physiology, Faculty of Medicine, Minia University, Minia, Egypt
Abstract
Background : Diabetes mellitus (DM) is a chronic metabolic condition defined by persistent hyperglycemia . Parkinsonism is a clinical syndrome with bradykinesia, static tremors, rigidity, and postural instability. Parkinson's disease is a neurological condition that progresses progressively over time. As people age, it becomes more common. Clinical symptoms remain the primary determinant of PD diagnosis. Aim and Objectives: This study aims to detect the effect of diabetes mellitus on model of Parkinson's disease (PD) in adult albino rats. Material and Methods: This study was a prospective controlled experiment done in the laboratory of the Medical Physiology department, under the college of Medicine at Minia University. The experiment involved a collective of 30 rats. Results: The diabetic Parkinson's group exhibited a statistically significant deterioration in Malondialdehyde (MDA) , Total antioxidant capacity (TAC), and Tumor necrosis factor-alpha (TNF-α) compared to the control group (C group), Parkinson's group (P group), and Diabetes Parkinson's group (DP group). Conclusion: Diabetes mellitus has a worsening effect on Parkinson’s disease.
Keywords
Diabetes mellitus (DM), Parkinson'; s disease (PD), Malondialdehyde (MDA), Total antioxidant capacity (TAC), Tumor necrosis factor-α (TNF-α )


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