Relationship between Locus of Control Belief and IL-6 in Breast Cancer Patients | ||||
Egyptian Journal of Cancer and Biomedical Research | ||||
Article 4, Volume 1, Issue 1 - Serial Number 5, October 2017, Page 21-24 PDF (243.44 K) | ||||
Document Type: Original Article | ||||
DOI: 10.21608/jcbr.2019.34733 | ||||
View on SCiNiTO | ||||
Authors | ||||
Azza EL-Amir 1; Mohamed L Salem 2; Noha L. Sabry3; Eman M. EL-Baiomy1; Nehal EL-Mashad4 | ||||
1Immunology Division, Faculty of Science, Cairo University, Egypt | ||||
2Immunology and Biotechnology Unit, Faculty of Science, Tanta University, Egypt | ||||
3Psychiatry Department, Faculty of Medicine, Cairo University, Egypt | ||||
4Oncology Department, Faculty of Medicine, Tanta University, Egypt | ||||
Abstract | ||||
Recent studies indicated to the immune disturbances in cancer patients in comparison with healthy individuals. Several studies suggested that individuals with external locus of control (E-LOC) have more symptoms of depression. Other studies indicated to the effective role of psychological status on the immune system. The association between E-LOC and immunity in cancer patients it is not clear. Study the relation between Rotter internal-external locus of control (I-E LOC) and God health locus of control (GHLC) and interleukin-6 (IL-6) in breast cancer patients. The study included hundred breast cancer patients and fifty healthy controls. Patients and participators responded to I-E LOC and GHLC questionnaires. Peripheral blood samples were collected to measure gene expression of IL-6 by using real time PCR. Breast cancer patients showed higher GHLC which was associated with higher level of IL-6 as compared to control subjects. By contrast, a significant inverse correlation between GHLC and IL-6 was found. However, there was no relationship between I-E LOC and IL-6. The results suggest no significant effect of LOC belief according to life on immune response against cancer, but high GHLC belief correlate with decreased IL-6. Further studies on the relations between other types of LOC and immune response in breast cancer is recommended. | ||||
Keywords | ||||
Locus of Control; breast cancer; IL-6 | ||||
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