Plasma MicroRNA-133a as a Potential Predictor for Coronary Artery Stenosis Severity | ||||
Zagazig University Medical Journal | ||||
Article 8, Volume 26, Issue 1, January and February 2020, Page 64-74 PDF (1.09 MB) | ||||
Document Type: Original Article | ||||
DOI: 10.21608/zumj.2019.13335.1238 | ||||
View on SCiNiTO | ||||
Authors | ||||
Heba Fawzy El Sayed Turky 1; Wafaa Abdel Latif Emam1; Sally M Shalaby 2; Nader Talaat Kandil3 | ||||
1Medical Biochemistry & Molecular Biology Department, Faculty of Medicine, Zagazig University | ||||
2Medical Biochemistry Department-Faculty of Medicine- Zagazig University-Egypt | ||||
3Cadiology Department , Faculty of Medicine , Zagazig University | ||||
Abstract | ||||
Background: Several scoring systems tried to determine coronary artery stenosis severity to investigate its correlation with laboratory parameters. Aim of the study: To investigate the correlation between the expression levels of circulating miRNA-133a & coronary artery stenosis severity . Patients and Methods: The study was conducted in Medical Biochemistry Department and Cardiology Department - Faculty of Medicine, Zagazig University& Medical Scientific Research Center. It included 72 subjects classified into 2 groups; Group (1): included 18 healthy subjects served as a control. Group (2 included 54 acute coronary syndrome patients. It was subdivided into 3 subgroups each 18 patient: unstable angina , non-ST-segment elevation myocardial infarction and ST-segment elevation myocardial infarction . Plasma miRNA-133a expression level was analyzed by real time PCR. Cardiac Cathetrization was done for showing the severity of stenosis. Results: The present study showed high significant positive correlation between miRNA-133a level and coronary stenosis percentage in unstable angina group (p | ||||
Keywords | ||||
ACS; STEMI; NSTEMI; real time PCR; miRNA 133a | ||||
Statistics Article View: 351 PDF Download: 490 |
||||