Evaluation of the Efficacy of Flowable Leukocyte and Platelet–Rich Fibrin versus Hyaluronic Acid as Bioactive Implant Coatings (Randomized Controlled Clinical Trial)

Bassiouny, Ghada; Abu Brika, Mahmoud; Ezzat, Mohamed; Hommos, Ahmed

doi:10.21608/edj.2024.267529.2920

	Evaluation of the Efficacy of Flowable Leukocyte and Platelet–Rich Fibrin versus Hyaluronic Acid as Bioactive Implant Coatings (Randomized Controlled Clinical Trial)
Egyptian Dental Journal
Volume 70, Issue 2 - Serial Number 3, April 2024, Page 1339-1353 PDF (2.01 MB)
Document Type: Original Article
DOI: 10.21608/edj.2024.267529.2920
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Authors
Ghada Bassiouny ¹; Mahmoud Abu Brika ²; Mohamed Ezzat ²; Ahmed Hommos ³
¹Associate Professor of Periodontology, Department of Oral Medicine, Periodontology, Oral Diagnosis and Radiology, Faculty of Dentistry, Alexandria University, Egypt
²B.D.S, clinical master of oral implantology , Faculty of Dentistry Alexandria University, Egypt
³Professor of Periodontology, Department of Oral Medicine, Periodontology, Oral Diagnosis and Radiology, Faculty of Dentistry Alexandria University, Egypt
Abstract
Background: osseointegrated dental implants are often left load-free during the healing period. Many trials have been conducted to improve osteointegration to minimize loading time and ultimately raise patient satisfaction. Aim of the Study: to assess the effectiveness of flowable L-PRF and hyaluronic acid as bioactive coatings for dental implants, to decrease loading time. Material and Methods: 30 sites indicated for implant placement in the mandibular posterior region were selected and divided into 3 groups. In test group I; 10 implants were coated with flowable L-PRF and in test group II; 10 implants were coated with Hyaluronic acid while in the negative control (group III) the remaining 10 implants were left uncoated. After osteotomy; all implants were installed. Clinical assessment of implant stability was carried out immediately post-insertion (primary stability) and then 2 and 3 months post-insertion (secondary stability) using Resonance Frequency Analysis. Radiographic assessment of marginal bone level was evaluated immediately post insertion and 3 months later before loading. Results: The results of this study revealed that implants coated with flowable L-PRF showed less marginal bone loss than those coated with hyaluronic acid or the uncoated ones (median of marginal bone loss at 3rd-month post insertion was 0.35mm, 0.37mm and 0.51mm respectively). On the other hand, implants coated with HA showed better secondary stability at 3rd-month post insertion with a median of (89.50) compared to (82.50) for flowable PRF and (79.00) for the uncoated control group. Conclusion: bioactive implant coatings can enhance osseointegration and decrease loading time.
Keywords
bio coatings; liquid PRF; Hyaluronic Acid; Marginal bone level; Implant Stability


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