ANTI-OSTEOPOROTIC OUTCOME OF FOSAMAX AND KLIMADYNON IN OSTEOPOROTIC RATS DURING TOOTH ERUPTION | ||||
| Egyptian Dental Journal | ||||
| Volume 70, Issue 2 - Serial Number 3, April 2024, Page 1377-1386 PDF (2.94 MB) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/edj.2024.268645.2932 | ||||
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| Authors | ||||
Noura Mohammed Bakr 1; Hoda Fansa 2; Abd Elrahman Sharfeldeen 3; Lashin Saad Ali 4; Zeinab Mahmoud Abulwafa  5; Abeer Abdelmaksoud Mohamed 6
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| 1Faculty of Dental Medicine for Girls, Al- Azhar University, Cairo, Egypt. | ||||
| 2Faculty of Dentistry, Al-Ahliyya Amman University, Jordan. Faculty of Dentistry, Alexandria University, Egypt. | ||||
| 3Faculty of Dentistry, Assiut University. Dental College, City University Ajman, Ajman, UAE. | ||||
| 4Faculty of Dentistry, Alexandria University, Egypt. Faculty of Medicine, Mansoura University, Egypt. | ||||
| 5Faculty of oral and dental medicine, Ahram Canadian University. | ||||
| 6Faculty of Dentistry, Fayoum University, Cairo, Egypt | ||||
| Abstract | ||||
| Objective: The study aimed to assess histologically and histomorphometrically the antiosteoporotic outcome of Fosamax and Klimadynon (black cohosh) in osteoporotic albino rats during tooth eruption. Methods: 12 female albino rats were divided into 4 equal groups: Negative Control group, Osteoporotic group: animals were injected by methyl-prednisolone subcutaneously for two months. Fosamax group: osteoporotic rats were treated simultaneously with oral Fosamax. Klimadynon group: osteoporotic rats were treated simultaneously with oral klimadynon. Pregnancy and delivery occurred during experiment, 40 offspring rats were divided into 4 equal groups, labelled from I to IV, each group was related to its corresponding mother' s group. Five rats from each offspring group were sacrificed at 7 and 14 days after their birth, the mandibles dissected and prepared for histopathological evaluation. Results: significant wearing away of the bone and diminution in the thickness of bone trabeculae were spotted in Group II in analogy to the control one. Group III showed remarkable improvement of the bone thickness over the erupting molars. While in group IV, the alveolar bone trbeculae were thin in structure. The highest mean values of bone thickness at 7 & 14 days were evident in the Fosamax group. Conclusion: The remarkable bone loss induced by Glucocorticoids could be compensated by Fosamax. Since black cohosh is a natural product, it is it is proposed to be used as a to be used as a favourable osteoprotective medication, however, it could cause delay in eruption but in a lesser degree than Fosamax. | ||||
| Keywords | ||||
| KEY WORDS: black cohosh; Fosamax; tooth eruption; osteoporosis | ||||
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