Effect of Eremina desertorum eggs extract on hepato-renal toxicity induced by cisplatin drug
El-Naggar, S., Basyouny, M., El Boserry, A., Elwan, M., Adam, R. (2024). Effect of Eremina desertorum eggs extract on hepato-renal toxicity induced by cisplatin drug. EKB Journal Management System, 2(2), 21-33. doi: 10.21608/bbj.2023.253335.1012
Sabry El-Naggar; Mohamed Basyouny; Ahmed El Boserry; Mona Elwan; Rahma Magdy Adam. "Effect of Eremina desertorum eggs extract on hepato-renal toxicity induced by cisplatin drug". EKB Journal Management System, 2, 2, 2024, 21-33. doi: 10.21608/bbj.2023.253335.1012
El-Naggar, S., Basyouny, M., El Boserry, A., Elwan, M., Adam, R. (2024). 'Effect of Eremina desertorum eggs extract on hepato-renal toxicity induced by cisplatin drug', EKB Journal Management System, 2(2), pp. 21-33. doi: 10.21608/bbj.2023.253335.1012
El-Naggar, S., Basyouny, M., El Boserry, A., Elwan, M., Adam, R. Effect of Eremina desertorum eggs extract on hepato-renal toxicity induced by cisplatin drug. EKB Journal Management System, 2024; 2(2): 21-33. doi: 10.21608/bbj.2023.253335.1012

Effect of Eremina desertorum eggs extract on hepato-renal toxicity induced by cisplatin drug

Biological and Biomedical Journal
Article 3, Volume 2, Issue 2, July 2024, Page 21-33  XML PDF (674.78 K)
Document Type: Research Articles
DOI: 10.21608/bbj.2023.253335.1012
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Authors
Sabry El-Naggarorcid 1; Mohamed Basyouny2; Ahmed El Boserry3; Mona Elwan4; Rahma Magdy Adam email 2
1Professor of Physiology, Zoology Department, Faculty of Science, Tanta University
2Zoology Department, Faculty of Science, Tanta University
3Zoology Deprtment
4Zoology Department
Abstract
Cisplatin (Cis) is a chemotherapeutic drug that has been used in the treatment of various types of cancers. However, the drug showed various toxic side effects on vital organs. This study aims to investigate the hepato-renal protective effect of Eremnia desertorum eggs powder (EDEP) in Ehrlich Ascites Carcinoma (EAC) bearing mice treated with Cis. Five groups of female Swiss albino mice were allotted as follows: Group (Gp1) served as a negative control, Gp2-Gp5 had inoculated intraperitoneally (i.p) with 1×106 EAC cells/mouse. Then, Gp2 was left without treatment as a positive control (EAC-bearing mice).  After 24 hours, Gp3, and Gp4 had injected i.p. with Cis (2 mg/kg) EDEP (500 mg/kg) daily for 7 consecutive days, respectively. Gp5 was injected with a combination of Cis/EDEP as in Gp3 and Gp4. All treated groups were sacrificed at day 12, and the percentage of the body weight changes (%b.wt), tumor indices, haematological and biochemical parameters, and antioxidant /oxidant biomarkers as well as histological alterations of liver and kidney tissues were investigated. The results showed that the % b.wt changes were increased in EAC-bearing mice and EAC-bearing mice that were treated with EDEP. While, the treatment of EAC-bearing mice with Cis decreased the % b.wt changes. The treatment of EAC-bearing mice with a combination of Cis/EDEP led to an improvement in AST, ALT, urea, creatinine, antioxidant enzyme activities, and ameliorated the histopathological toxicities in the liver and kidneys in EAC-bearing mice.
Keywords
Antioxidants; Cisplatin; EAC-cells; Eggs; Eremina desertorum; Hepato-renal protective; Powder
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