Solanum melongena Peels against Ethanol Induced Gastric Ulcer in Rats via Regulating Mucosal Enzymes, Oxidative Stress and Inflammatory Mediators' Pathways | ||||
| Egyptian Journal of Chemistry | ||||
| Volume 67, Issue 10, October 2024, Page 587-600 PDF (637.99 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/ejchem.2024.271316.9354 | ||||
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| Authors | ||||
Amal M. El-Feky 1; Asmaa F. Aboul Naser2; Manal A. Hamed  2
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| 1Department of Pharmacognosy, National Research Centre, Dokki, Giza, Egypt. | ||||
| 2Department of Therapeutic Chemistry, National Research Centre, Dokki, Giza, Egypt. | ||||
| Abstract | ||||
| Peels from Solanum melongena L. (eggplant) contain a variety of strong active components that are beneficial to human health. This study aimed to determine the potential effect of eggplant peels in treating stomach ulcers in rats. Phenolics, flavonoids, and anthocyanins as bioactive compounds were quantified in the acidified alcoholic extract of eggplant peels. In addition, identification of the isolated compounds was performed by HPLC and LC-ESI-MS analyses. The biochemical evaluation was done through measuring stomach acidity (PH), gastric volume, lesion counts, glutathione (GSH), superoxide dismutase (SOD), malondialdehyde (MDA), succinate dehydrogenase (SDH), lactate dehydrogenase (LDH), acid phosphatase (AP), tumor necrosis factor alpha (TNF-α) and prostaglandin E2 (PGE2). Stomach histopathological features were also monitored. Twenty-six compounds (six phenolic acids, 12 flavonoids, and 8 anthocyanin compounds were identified. For the first time, four compounds (kaempferol, quercetin, 5-hydroxy-3,7,4′-trimethoxyflavone, and kaempferol-3-O-glucoside) and one known compound; quercetin 3-O-glucoside were isolated from the eggplant peels. Rats given methanolic extract from the peels of Solanum melongena L. show variable improvements in all biochemical parameters as well as in the histological characteristics of the stomach. In conclusion, Solanum melongena L. peels could be considered as a nutraceutical agent against stomach ulcers. Confirming the chemical responsible for its therapeutic activity will require additional research. | ||||
| Keywords | ||||
| Solanum melongen; flavonoids; anthocyanin; ethanol; stomach ulcer; oxidative stress | ||||
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