Therapeutic Effect of Punica granatum Peels Extract against Nephropathy Induced by Streptozotocin in Rats.

El-Toumy, Sayed Abdel Hamid; Salib, Josline Yehia; Salama, Abeer Abd-Allaha; Omara, Enayat Abdel Aziz; Hassan, Emad Mohamed

doi:10.21608/ejchem.2024.271529.9362

	Therapeutic Effect of Punica granatum Peels Extract against Nephropathy Induced by Streptozotocin in Rats.
Egyptian Journal of Chemistry
Articles in Press, Accepted Manuscript, Available Online from 01 April 2024
Document Type: Original Article
DOI: 10.21608/ejchem.2024.271529.9362
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Authors
Sayed Abdel Hamid El-Toumy ¹; Josline Yehia Salib ²; Abeer Abd-Allaha Salama ³; Enayat Abdel Aziz Omara ⁴; Emad Mohamed Hassan ⁵
¹Chemistry of Tannins Department, National Research Centre;
²Chemistry of Tannins Department, National Research Center
³Pharmacology Department, National Research Centre;
⁴Pathology Department, National Research Center; 12622 Dokki, Cairo, Egypt.
⁵Medicinal and Aromatic Plants Research Department, National Research Centre
Abstract
The present study investigated the effects of P. granatum peels extract on streptozotocin-induced diabetic rats for 21 days, as well as the biochemical, histopathological and immuno-histochemical effects in the kidney tissues. The aqueous methanol extract of P. granatum peels was administrated to STZ diabetes rats at doses of (100 and 200 mg/kg), using Amaryl as standard drug. After treatment, blood glucose, serum insulin, urea, creatinine, TNF-α, and Enzymatic scavengers’ levels were measured. Diabetic rats given P. granatum extract had their fasting blood glucose and kidney antioxidant status reduced in a dose-dependent manner. Rats given P. granatum peel extract revealed substantially fewer histopathological observations than the diabetic control group, including tubular dilatation, tubular epithelium necrosis, glomerular atrophy, and interstitial inflammation. Moreover, after the administration of P. granatum extract (200 mg/kg), inducible nitric oxide synthase (iNOS) levels dropped significantly. Thus, the anti-hyperglycemic and antioxidant properties of P. granatum extract may expand the potential source for diabetes treatment.
Keywords
Anti-hyperglycemic, antioxidant properties; Punica granatum peels; streptozotocin-induced, diabetic rats


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