EVALUATION OF EFFICACY COMBINATION OF ZNO NANOPARTICLES AND RESISTED ANTIBIOTICS AGAINST AVIAN PATHOGENIC E.COLI | ||||
| Assiut Veterinary Medical Journal | ||||
| Article 15, Volume 70, Issue 181, April 2024, Page 166-178 PDF (1.42 MB) | ||||
| Document Type: Research article | ||||
| DOI: 10.21608/avmj.2024.269560.1226 | ||||
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| Authors | ||||
AML BADRY1; AWAD ABD EL HAFEZ IBRAHIM2; YASMIN OMAR MAHMOUD EL-AMIR3; ASMAA A. E. NASR4; AHMED, K. HASSAN5; MARWA, M. SAFWAT   2
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| 1Veterinarian, Avian and Rabbit Medicine Department, Faculty of Veterinary Medicine, Assiut University. Egypt | ||||
| 2Avian and Rabbit Medicine Department, Faculty of Veterinary Medicine, Assiut University. Egypt. | ||||
| 3Department of Pathology and Clinical Pathology, Veterinary Medicine, Assiut University. Egypt | ||||
| 4Poultry Diseases Department, Animal Health Research Institute, Assiut, Egypt. | ||||
| 5Avian and Rabbit Medicine Department, Faculty of Veterinary Medicine, Assiut University. Assiut, Egypt | ||||
| Abstract | ||||
| The antibiotic resistance of Avian Pathogenic E. coli is considered one of the biggest public health concerns worldwide and with the growing necessity to find unconventional approaches for formulating new forms of safe and price of effective antibiotics for monitoring the spread of resisted pathogens globally, zinc oxide (ZnO) has the prospective to influence many aspects because of their antimicrobial efficacy. Therefore, our study is intended to evaluate the in vivo antibacterial activity of the chemically synthesized PEG-6000 coated-ZnO nanoparticles in low (11.6mg/ml) and high (23mg/ml) doses alone and in combination with florfincol and streptomycin, experimentally. The obtained results showed that oral administration of a low dose of ZnO NPs (11.6 mg/ml) alone or with florfincol and streptomycin revealed mild efficacy against APEC infection, while a high dose of ZnO-NPs (23 mg/ml) whether alone or combined with florfincol and streptomycin for 3 days of treatment, gave good improvement, that was confirmed grossly, and by histopathological inspection of the liver and kidney. It could be concluded that not only do PEG-6000 Coated ZnO NPs have a powerful antibacterial effect against APEC in broilers, but they also can enhance the antibacterial activity of resisted antibiotics. The obtained results showed that oral administration of a low dose of ZnO NPs (11.6 mg/ml) alone or with florfincol and streptomycin revealed mild efficacy against APEC infection, while a high dose of ZnO-NPs (23 mg/ml) whether alone or combined with florfincol and streptomycin for 3 days of treatment, gave good improvement, that was confirmed grossly, and by histopathological inspection of the liver and kidney. It could be concluded that not only do PEG-6000 Coated ZnO NPs have a powerful antibacterial effect against APEC in broilers, but they also have the ability to enhance the antibacterial activity of resisted antibiotics. | ||||
| Keywords | ||||
| APEC; ZnO Nanoparticles; Histopathology; Broiler | ||||
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