COMPARATIVE STUDY OF IMMUNOHISTOCHEMICAL EXPRESSION OF GP88 AND Cath-D AS PROGNOSTIC MARKERS AND CORRELATION WITH PATHOLOGICAL AND HISTOLOGICAL PARAMETERS IN HUMAN BREAST CANCER
Al-Qadasi, S., Yahia, M., Mohamed, S., Sultan, R. (2024). COMPARATIVE STUDY OF IMMUNOHISTOCHEMICAL EXPRESSION OF GP88 AND Cath-D AS PROGNOSTIC MARKERS AND CORRELATION WITH PATHOLOGICAL AND HISTOLOGICAL PARAMETERS IN HUMAN BREAST CANCER. EKB Journal Management System, 6(2), 67-86. doi: 10.21608/jmals.2024.349436
Sabah Ali Mugahed Al-Qadasi; Mona Abd Alhamed Yahia; Saeed Mahmoud Saeed Mohamed; Roa Mohmed Mahmoud Sultan. "COMPARATIVE STUDY OF IMMUNOHISTOCHEMICAL EXPRESSION OF GP88 AND Cath-D AS PROGNOSTIC MARKERS AND CORRELATION WITH PATHOLOGICAL AND HISTOLOGICAL PARAMETERS IN HUMAN BREAST CANCER". EKB Journal Management System, 6, 2, 2024, 67-86. doi: 10.21608/jmals.2024.349436
Al-Qadasi, S., Yahia, M., Mohamed, S., Sultan, R. (2024). 'COMPARATIVE STUDY OF IMMUNOHISTOCHEMICAL EXPRESSION OF GP88 AND Cath-D AS PROGNOSTIC MARKERS AND CORRELATION WITH PATHOLOGICAL AND HISTOLOGICAL PARAMETERS IN HUMAN BREAST CANCER', EKB Journal Management System, 6(2), pp. 67-86. doi: 10.21608/jmals.2024.349436
Al-Qadasi, S., Yahia, M., Mohamed, S., Sultan, R. COMPARATIVE STUDY OF IMMUNOHISTOCHEMICAL EXPRESSION OF GP88 AND Cath-D AS PROGNOSTIC MARKERS AND CORRELATION WITH PATHOLOGICAL AND HISTOLOGICAL PARAMETERS IN HUMAN BREAST CANCER. EKB Journal Management System, 2024; 6(2): 67-86. doi: 10.21608/jmals.2024.349436

COMPARATIVE STUDY OF IMMUNOHISTOCHEMICAL EXPRESSION OF GP88 AND Cath-D AS PROGNOSTIC MARKERS AND CORRELATION WITH PATHOLOGICAL AND HISTOLOGICAL PARAMETERS IN HUMAN BREAST CANCER

Journal of Medical and Life Science
Volume 6, Issue 2, June 2024, Page 67-86  XML PDF (2.46 MB)
Document Type: Original Article
DOI: 10.21608/jmals.2024.349436
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Authors
Sabah Ali Mugahed Al-Qadasi* 1; Mona Abd Alhamed Yahia2; Saeed Mahmoud Saeed Mohamed3; Roa Mohmed Mahmoud Sultan4
1Assistant Professor of Histology, Anatomy and Histology Department, Faculty of Medicine and Health Sciences, Sana'a University, Sana'a, Yemen.
2Professor of Histochemistry and Cell Biology Department, Medical Research Institute, University of Alexandria, Egypt.
3Assistant Professor of Histopathology and Cytology Department, Faculty of Medical Laboratory Sciences, West Kurdofan University, Sudan.
4Lecturer of Histopathology and Cytology Department, Faculty of Medical Laboratory Sciences, Sudan International University, Khartoum- Sudan.
Abstract
Progranulin or acrogranin is an 88-kDa glycoprotein identified by a biological screen for protein targets associated with high tumorigenicity. Cathepsin D (Cath-D) is a soluble lysosomal aspartyl glycoprotease that can degrade the protein components of the matrix and free growth factors therein embedded, thus favoring tumor growth, invasion, and angiogenesis. The present work aimed to compare the expression of GP88 and Cath-D as novel prognostic biomarkers in human invasive ductal carcinoma (IDC) versus benign tumors and normal breast tissues as well as their correlation with different pathological and histological parameters. The immunohistochemical technique was used to examine the expression of GP88 and Cath-D in normal, benign, and IDC. Present results showed higher expression of GP88, and Cath-D in IDC compared to normal and benign breast tissues.
Keywords
GP88 and Cath; D prognostic marker
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