Effect of fractional CO2 laser combined with 5-Fluorouracil injection in the treatment of Hypertrophic Scars and Keloids.. | ||||
| Fayoum University Medical Journal | ||||
| Volume 13, Issue 1, January 2024, Page 38-51 PDF (349.13 K) | ||||
| Document Type: Review Articles | ||||
| DOI: 10.21608/fumj.2024.240936.1269 | ||||
 View on SCiNiTO | ||||
| Authors | ||||
mai Sameh mohamed kamal Attia   1; Talal Ahmed Abd El Raheem2; Mahmoud Saber Elbasiouny3
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| 1Dermatology and Andrology department, Faculty of medicine, Fayoum university | ||||
| 2Dermatology, STDs and Andrology Department, Faculty of Medicine, Fayoum University, Fayoum, Egypt. | ||||
| 3Professor of Plastic Surgery, Department of Medical Applications of Laser (MAL) National Institute of Laser Enhanced Science (NILES) – Cairo University | ||||
| Abstract | ||||
| Background: Hypertrophic scars (HTSs) and keloids are prevalent dermatological complaints caused by alternation of the normal process of wound-healing. Aim: To determine the comparative effects of ablative fractional carbon dioxide laser combined with Injection of 5-fluorouracil versus intralesional injection of 5- fluorouracil and ablative fractional CO2 laser each as monotherapy in the treatment of hypertrophic scars and keloids. Patients and Methods: Thirty patients with hypertrophic scars and keloids were collected and divided into 3 groups each group included 10 patients. Group A: which is the main purpose of the study was treated by intralesional 5-Fluorouracil plus ablative fractional carbon dioxide Laser. Group B: treated by ablative fractional carbon dioxide Laser as a monotherapy. Group C: treated by intralesional 5-Fluorouracil as a monotherapy. Assessment of results was done using Vancouver scar scale (VSS), Observer Scar Assessment scale and Patient Scar Assessment Scale (POSAS). Results: Comparison between VSS before and after treatment showed a significant improvement between study groups. After completion of treatment there was a statistically significant difference reported between the three groups with p value 0.0001. Improvement after completion of treatment was observed to favor group A followed by group B and group C. Conclusion: 5FU injection plus Fractional CO2 laser showed the highest improvement percentage among all groups. Fractional CO2 laser showed acceptable results in management of hypertrophic scars. Intralesional 5FU injection as a monotherapy was accompanied with the highest incidence of complications and decline in the evaluating scores (VSS and POSAS). | ||||
| Keywords | ||||
| Fractional CO2 Laser; 5-Fluorouracil Injection; Hypertrophic Scars, Keloids | ||||
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