Changes in histopathological phenotypes of Schistosoma-associated urinary bladder cancer in Sohag, Egypt | ||||
| Parasitologists United Journal | ||||
| Articles in Press, Accepted Manuscript, Available Online from 11 April 2024 | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/puj.2024.265820.1236 | ||||
 View on SCiNiTO | ||||
| Authors | ||||
Asmaa Kamal Abd Ellah  1; Maisa Hashem Mohammed2
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| 1medical parasitology department, faculty of medicine ,sohag university | ||||
| 2Pathology Department , Faculty of Medicine, Sohag University, Egypt | ||||
| Abstract | ||||
| Background: Bilharzial bladder carcinoma is the most common cancer, especially in Egyptian men. Classically, carcinoma in a bilharzial bladder is most commonly of the squamous cell type. However, over the years, there are a proved changing pattern of Schistosoma associated bladder cancer (SA-BC) that need to be investigated. The aim of this study was to assess the patterns (age, incidence and histopathological types) of SA-BC in Sohag, Egypt from 2019 to 2022. Methods: This was a descriptive retrospective study of histologically confirmed cases of urinary bladder cancer (BC) diagnosed at the Pathology Department of Sohag University Hospital, from January 2019 to December 2022. Data were retrieved from the records of Pathology Department. Results: A total of 152 patients were diagnosed with urinary BC during the study period. Their age ranged from 35-79 years old with the mean age of 61.2 ± 9.1 years and male to female ratio was about 4.6:1. Transitional cell carcinoma (TCC) was the most common histological type (80.9%) followed by squamous cell carcinoma (SCC) (12.5 %) and TCC with squamous differentiation (6.5%). Schistosomiasis was histologically confirmed in 39.4% of cancer cases; 76.6% were TCC, 21.6% were SCC and only 1.6% was TCC with squamous differentiation. All cases were male and their mean age was 59.8 ±7.5. At the time of diagnosis, 96.6 % of SA-BC cases were bladder muscle invasive and 91.6 % of the cases were high-grade nature which were not significantly different from cases with non-Schistosome associated bladder cancer (NSA-BC) (p < 0.9, p < 0.9 respectively). Conclusions: The histopathological patterns of SA-BC have changed in Egypt over the past decade and old concept that schistosomiasis was associated with SCC should be revaluated as most cases were associated with TCC. Keywords: Urinary Schistosomiasis, bladder cancer, TCC: transitional cell carcinoma, SCC: squamous cell carcinoma, Sohag, Egypt. | ||||
| Keywords | ||||
| Urinary Schistosomiasis; bladder cancer; TCC: transitional cell carcinoma; SCC: squamous cell carcinoma; Sohag; Egypt | ||||
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