Significance of Sex Determining Region Y-Box transcription factor 4 (SOX4) expression and Nuclear morphometry in endometrial carcinoma | ||||
| Benha Medical Journal | ||||
| Article 14, Volume 41, Issue 2, May and June 2024, Page 151-167 PDF (1.87 MB) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/bmfj.2024.270708.2019 | ||||
 View on SCiNiTO | ||||
| Authors | ||||
Rana M. Abdalla1; Maram T. Alhady  2; Heba M. Rashad3; Nashwa M. Emarah1; Naglaa H .Shalan1
| ||||
| 1Department of anatomic Pathology, Faculty of medicine, Benha University | ||||
| 2Department of M.B.B.CH anatomic Pathology, Faculty of medicine, Benha University | ||||
| 3Department of anatomic Pathology, Faculty of medicine, Banha University. | ||||
| Abstract | ||||
| Background: Endometrial carcinoma (EC) is the 6th most common cancer worldwide. SOX4 has been used as an immunohistochemical marker. Expression of SOX4 by cancer cells has been demonstrated in EC. Nuclear morphometry is an imaging technique that plays important roles in endometrial hyperplasia (EH) and EC. Aim: This work aims to evaluate SOX4 expression and nuclear morphometry in EH and EC and the relation between its expression and different clinicopathological variables. Material and method: This is a selected retrospective study including 60 different cases of EC and EH. SOX4 immunostaining and nuclear morphometry were performed for all cases. Results: There was a highly significant statistical difference between SOX4 expression in studied cases according to type, FIGO grade, depth of myometrial invasion, LVSI, T/B configuration, desmoplasia, mitotic count, T, N, M components, TNM and FIGO stage (P | ||||
| Keywords | ||||
| Endometrial hyperplasia; endometrial carcinoma; SOX4; nuclear morphometry | ||||
|
Statistics Article View: 34 PDF Download: 25 |
||||
