THE DIVERSE ROLES OF MUCOSAL-ASSOCIATED INVARIANT T LYMPHOCYTES IN HEMATOLOGICAL MALIGNANCIES
Ahmed, A., Bakr Badawy, O., El Mokhtar, M., Ahmed, O., Sabet, M., Zahran, A., Seif Eldin, S. (2024). THE DIVERSE ROLES OF MUCOSAL-ASSOCIATED INVARIANT T LYMPHOCYTES IN HEMATOLOGICAL MALIGNANCIES. EKB Journal Management System, 47(1), 571-584. doi: 10.21608/bfsa.2024.272271.2041
Ali A Ahmed; Omnia Hasan Bakr Badawy; Mohamed El Mokhtar; Omer A Ahmed; Marwa Sabet; A M Zahran; Salwa Seif Eldin. "THE DIVERSE ROLES OF MUCOSAL-ASSOCIATED INVARIANT T LYMPHOCYTES IN HEMATOLOGICAL MALIGNANCIES". EKB Journal Management System, 47, 1, 2024, 571-584. doi: 10.21608/bfsa.2024.272271.2041
Ahmed, A., Bakr Badawy, O., El Mokhtar, M., Ahmed, O., Sabet, M., Zahran, A., Seif Eldin, S. (2024). 'THE DIVERSE ROLES OF MUCOSAL-ASSOCIATED INVARIANT T LYMPHOCYTES IN HEMATOLOGICAL MALIGNANCIES', EKB Journal Management System, 47(1), pp. 571-584. doi: 10.21608/bfsa.2024.272271.2041
Ahmed, A., Bakr Badawy, O., El Mokhtar, M., Ahmed, O., Sabet, M., Zahran, A., Seif Eldin, S. THE DIVERSE ROLES OF MUCOSAL-ASSOCIATED INVARIANT T LYMPHOCYTES IN HEMATOLOGICAL MALIGNANCIES. EKB Journal Management System, 2024; 47(1): 571-584. doi: 10.21608/bfsa.2024.272271.2041

THE DIVERSE ROLES OF MUCOSAL-ASSOCIATED INVARIANT T LYMPHOCYTES IN HEMATOLOGICAL MALIGNANCIES

Bulletin of Pharmaceutical Sciences Assiut University
Article 38, Volume 47, Issue 1, June 2024, Page 571-584  XML PDF (1.08 MB)
Document Type: Review Article
DOI: 10.21608/bfsa.2024.272271.2041
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Authors
Ali A Ahmed email 1; Omnia Hasan Bakr Badawy2; Mohamed El Mokhtarorcid 3; Omer A Ahmed4; Marwa Sabet5; A M Zahran6; Salwa Seif Eldin2
1Microbiology and Immunology Department, Faculty of Pharmacy, Assiut University, Assiut, Egypt
2Department of Medical Microbiology and Immunology, Faculty of medicine, Assiut University, Assiut, Egypt
3Medical Microbiology and Immunology Department, Faculty of Medicine, Assiut University, Assiut, Egypt, Gilbert & Rose-Marie Chagoury School of Medicine, Lebanese American University, Byblos, Lebanon
4Department of Pharmacy, Al-Mansha Central Hospital, Sohag Health Directorate, Sohag, Egypt
5Department of Microbiology and Immunology, Faculty of Pharmacy, Sphinx University, New-Assiut, Egypt
6Department of clinical pathology, South Egypt cancer Institute, Assiut, University, Assiut 71515, Egypt.
Abstract
The majority of studies on Novel Mucosal-associated invariant T (MAIT) cells have focused on their involvement in solid tumours; however, the role and significance of MAIT cells in hematological malignancies are not well understood and have not been thoroughly investigated. MAIT cells is a population of αβ T cells that recognize non-peptide antigens presented by the non-polymorphic MR1 molecule. They are characterized by the expression of Vα7.2 together with high expression of the CD161. MAIT cells have been linked to a variety of tumours including, solid tumours such as hepatocellular carcinoma, colorectal, lung and kidney cancers and their frequencies in the tumour sites appeared to correlate with prognosis. MAIT cells were also studied in hematological malignancies such as multiple myeloma and leukaemia. In this review we will outline our current understanding of the relationship between MAIT cells and hematological malignancies, which will underline the possibility of targeting this subset for modern immunotherapy development.
Keywords
MAIT cells; Acute myeloid leukemia (AML); Vα 7.2; IFN; GrB and Immunotherapy
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