Significance of Transmembrane 9 Superfamily 4 (TM9SF4) immunohistochemical expression and nuclear morphometry in premalignant colonic lesions and colorectal carcinoma | ||||
| Benha Medical Journal | ||||
| Articles in Press, Accepted Manuscript, Available Online from 13 April 2024 PDF (628.02 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/bmfj.2024.267320.2010 | ||||
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| Authors | ||||
Naglaa H .Shalan1; Norhan Mosaad Morgan  2; Rasha M.Abdrabh1; Abd ElLatif M. Elbalshy1; Rana M. Abdalla1
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| 1Department of anatomic Pathology, Faculty of medicine, Benha University | ||||
| 2M.B.B.CH anatomic Pathology, Faculty of medicine, Benha University | ||||
| Abstract | ||||
| Background: Although different markers are used as diagnostic methods for CRC such as; carcinoembryonic antigen (CEA) and carbohydrate antigen 19-9 (CA 19-9), low sensitivity and low specificity of these markers revealed the importance of searching for other markers. Transmembrane 9 Superfamily 4 (TM9SF4) is autophagic protein involved in multiple stages of tumorigenesis and development. Nuclear morphometry is a method for digital histological analysis which has been subjected to significant technological advances in the last years. Aim: To evaluate Transmembrane 9 Superfamily 4 (TM9SF4) IHC expression and nuclear morphometry in premalignant colonic lesions and colorectal carcinoma. Material and methods: This is a retrospective study carried on 23 colorectal adenocarcinomas, 16 colonic adenomas, 11 ulcerative colitis and 6 normal colon cases as a control. Clinicopathological characteristics of examined cases were correlated with IHC of TM9SF4 and nuclear morphometry. Results: There is a significant statistical correlation between TM9SF4 scoring and different types of studied cases, lymphovascular invasion, lymph node metastasis, distant metastasis and stage of CRC. There is a significant statistical correlation between CRC and premalignant cases regarding nuclear morphometry. Also, there is a significant statistical correlation between area and perimeter nuclear morphometry and perineural invasion and grade of colorectal adenocarcinoma respectively. Conclusion: The results suggested that TM9SF4 has role in tumorigenesis and CRC development and also has a prognostic role in CRC while, nuclear morphometry has a diagnostic role with nuclear morphometry being better than TM9SF4. | ||||
| Keywords | ||||
| Keywords: Colorectal adenocarcinoma; Transmembrane 9 Superfamily 4; nuclear morphometry | ||||
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