Salvia officinalis essential oil extract attenuates cisplatin-induced hepatorenal damage via modulating oxidative stress and apoptosis.
Adel Mohamed Mahmoud, N., Salah, E., Farag, E., Elkomy, A., s. ibrahim, S. (2024). Salvia officinalis essential oil extract attenuates cisplatin-induced hepatorenal damage via modulating oxidative stress and apoptosis.. EKB Journal Management System, 46(1), 20-25. doi: 10.21608/bvmj.2024.269769.1786
Nissrin Adel Mohamed Mahmoud; Eman Salah; Enas A.H. Farag; Ashraf Elkomy; samar s. ibrahim. "Salvia officinalis essential oil extract attenuates cisplatin-induced hepatorenal damage via modulating oxidative stress and apoptosis.". EKB Journal Management System, 46, 1, 2024, 20-25. doi: 10.21608/bvmj.2024.269769.1786
Adel Mohamed Mahmoud, N., Salah, E., Farag, E., Elkomy, A., s. ibrahim, S. (2024). 'Salvia officinalis essential oil extract attenuates cisplatin-induced hepatorenal damage via modulating oxidative stress and apoptosis.', EKB Journal Management System, 46(1), pp. 20-25. doi: 10.21608/bvmj.2024.269769.1786
Adel Mohamed Mahmoud, N., Salah, E., Farag, E., Elkomy, A., s. ibrahim, S. Salvia officinalis essential oil extract attenuates cisplatin-induced hepatorenal damage via modulating oxidative stress and apoptosis.. EKB Journal Management System, 2024; 46(1): 20-25. doi: 10.21608/bvmj.2024.269769.1786

Salvia officinalis essential oil extract attenuates cisplatin-induced hepatorenal damage via modulating oxidative stress and apoptosis.

Benha Veterinary Medical Journal
Article 4, Volume 46, Issue 1, April 2024, Page 20-25  XML PDF (1.02 MB)
Document Type: Original Article
DOI: 10.21608/bvmj.2024.269769.1786
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Authors
Nissrin Adel Mohamed Mahmoud email 1; Eman Salah1; Enas A.H. Farag2; Ashraf Elkomy1; samar s. ibrahimorcid 3
1Department of Pharmacology, Faculty of Veterinary Medicine, Benha University
2Animal Health Research Institute for regional laboratories
3Department of Forensic Medicine and Toxicology, Faculty of Veterinary Medicine, Benha University
Abstract
Cisplatin is one of the most powerful drugs used in cancer treatment, and it has several side effects, including hepatotoxicity and nephrotoxicity. This study aimed to see if salvia officinalis essential oil extract might protect rats' liver and kidneys against cisplatin damage. Twenty–four male albino rats were divided into 4 groups (6 rats each). G1(control), G2(salvia officinalis essential oil extract), G3(cisplatin), G4(cisplatin+ salvia officinalis essential oil extract). Cisplatin treated rats showed increased serum ALT, AST, ALP, cholesterol, triglyceride, LDL- cholesterol, creatinine and urea concentrations and decreased total protein and albumin concentration. Moreover, cisplatin treated rats significantly increased levels of MDA and decreased SOD and CAT levels in hepatic and renal tissue compared to the control group. Salvia officinalis essential oil extract administration at a dose of (100mg extract of salvia officinalis L./kg.b.wt.) with once intraperitoneal (7.5 mg cisplatin/kg.b.wt.) at the day 10th of the experiment renormalized and reversed the hepatorenal damage induced by cisplatin group due to its antioxidant and anti-inflammatory effects. Histopathological alteration and Immunohistochemistry (TNF alpha) examination showed improvement in the microscopic pictures of both liver and kidneys after using salvia officinalis essential oil extract.
Keywords
Gas-chromatography; TNF alpha; Sage plant; Immunohistochemistry; Histopathology
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