New Design and Synthesis of a Variety of 1,2,4-Triazole Thiol Derivatives: Studying their Antimicrobial and Potential Cytotoxic Effect
Soliman, Z., Kamel, E., Hosny, M., El Farargy, A., Mokbel, W. (2024). New Design and Synthesis of a Variety of 1,2,4-Triazole Thiol Derivatives: Studying their Antimicrobial and Potential Cytotoxic Effect. EKB Journal Management System, 67(10), 601-617. doi: 10.21608/ejchem.2024.275486.9423
Zainab Adel Soliman; Emadeldin Mohamed Kamel; Mona Amin Hosny; Ahmed F. El Farargy; Wafaa Abd El badi Mokbel. "New Design and Synthesis of a Variety of 1,2,4-Triazole Thiol Derivatives: Studying their Antimicrobial and Potential Cytotoxic Effect". EKB Journal Management System, 67, 10, 2024, 601-617. doi: 10.21608/ejchem.2024.275486.9423
Soliman, Z., Kamel, E., Hosny, M., El Farargy, A., Mokbel, W. (2024). 'New Design and Synthesis of a Variety of 1,2,4-Triazole Thiol Derivatives: Studying their Antimicrobial and Potential Cytotoxic Effect', EKB Journal Management System, 67(10), pp. 601-617. doi: 10.21608/ejchem.2024.275486.9423
Soliman, Z., Kamel, E., Hosny, M., El Farargy, A., Mokbel, W. New Design and Synthesis of a Variety of 1,2,4-Triazole Thiol Derivatives: Studying their Antimicrobial and Potential Cytotoxic Effect. EKB Journal Management System, 2024; 67(10): 601-617. doi: 10.21608/ejchem.2024.275486.9423

New Design and Synthesis of a Variety of 1,2,4-Triazole Thiol Derivatives: Studying their Antimicrobial and Potential Cytotoxic Effect

Egyptian Journal of Chemistry
Volume 67, Issue 10, October 2024, Page 601-617  XML PDF (1.32 MB)
Document Type: Original Article
DOI: 10.21608/ejchem.2024.275486.9423
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Authors
Zainab Adel Soliman email orcid 1; Emadeldin Mohamed Kamel2; Mona Amin Hosny3; Ahmed F. El Farargy4; Wafaa Abd El badi Mokbel3
1Chemistry Department, Faculty of women for Arts, Science and Education, Ain Shams University
2Department of Chemistry, Faculty of Science, Beni-Suef University, Beni-Suef 62514, Egypt.
3Department of Chemistry, Faculty of Women for Arts, Science and Education, Ain Shams University, Heliopolis, Cairo 11757, Egypt.
4Chemistry Department, Faculty of Science, Zagazig University, Zagazig 44519, Egypt.
Abstract
Abstract

1,2,4-Triazole-3-thiols have recently garnered sufficient concern due to their cytotoxic and antimicrobial properties, rendering them valuable in aspects of medicine and pharmacology. The interaction of phenyl hydrazine and benzoyl isothiocyanate (1) yielded 1,5-diphenyl-1H-1,2,4-triazole-3-thiol (2), which upon treatment with hydrazine monohydrate after exposure to ethyl-chloroacetate, acetohydrazide (4) was achieved, that was taken into consideration as a raw substance for creating new derivatives (5–9) by interacting with carbon disulfide, isatin, glucose, phthalic anhydride, and various aldehydes. The spectroscopic analysis encompassing (IR, Mass spectrum, 1H-NMR, and 13C-NMR) for those newly synthesized compounds and their behavior against bacteria, fungi, and breast cancer cell lines are covered in this study. Moreover, molecular docking investigation of the antimicrobial action and the structure-activity relationships SAR based on cytotoxic impact are mentioned and discussed.
Keywords
oxadiazole; Schiff-base; antimicrobial assay; antitumor; molecular docking
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