A Review of Iridoid Glycosides Content and Their Biological Properties from Genus Citharexylum

Abd-Alla, Howaida Ibrahim; Saad, Safaa A.; Shalaby, Nagwa M.M.; Aly, Hanan Farouk; Abdel-Moein, Nadia M.; Afify, Abd El-Moneim M.; Ali, Hanaa F. M.

doi:10.21608/ejchem.2024.272834.9391

	A Review of Iridoid Glycosides Content and Their Biological Properties from Genus Citharexylum
Egyptian Journal of Chemistry
Articles in Press, Accepted Manuscript, Available Online from 15 April 2024
Document Type: Review Articles
DOI: 10.21608/ejchem.2024.272834.9391
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Authors
Howaida Ibrahim Abd-Alla ¹; Safaa A. Saad²; Nagwa M.M. Shalaby ²; Hanan Farouk Aly ³; Nadia M. Abdel-Moein⁴; Abd El-Moneim M. Afify⁵; Hanaa F. M. Ali⁴
¹Natural Compounds Chemistry Department, National Research Centre, Dokki, Giza, Egypt
²Natural Compounds Chemistry Department, NRC
³Deprtment of Therapeutic Chemistry , National Research Centre (NRC),El Behouth St. , P.O.12622. Dokki, Giza, Egypt.
⁴Biochemistry Department, Faculty of Agriculture, Cairo University, Egypt
⁵1Biochemistry Department, Faculty of Agriculture, Cairo University, Egypt
Abstract
Citharexylum is a genus of flowering plants that belongs to Verbenaceae family. Various species of genus Citharexylum are cultivated as ornamentals. The species have various potent pharmacological and biological activities such as antioxidant, antidiabetic, antibacterial, anticancer and antipyretic effects. The Citharexylum botanical genus is a rich source of iridoid glycosides. All of the iridoids isolated from Citharexylum species have a- mono-glucosidic structure. The activity such as antinociceptive, antimicrobial, antischistosomal, cytotoxic, anticancer, hepatoprotective, nephroprotective, antispasmodic, muscle relaxation, antidiabetic, antiallergic, immunomodultory, antityrosinase and anticholinesterase was discussed. The study extended to the application of plant with high content of iridoid glycosides as well as the further search and future perspective. This review provides an exhaustive compilation of the iridoid glycosides-containing species of Citharexylum along with conjectures regarding potential biological activities, particularly those related to antioxidant and anti-inflammatory properties. The structure-activity relationships as anti-inflammatory and antioxidant agents have been illustrated.
Keywords
Citharexylum; iridoid glycosides; biological activities; anti-inflammatory; antioxidant, structure-activity relationship, future prospective


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