Impact Of Type 2 Diabetes Mellitus On Activated Partial Thromboplastin Time and Serum Fibrinogen In Non-dialysis Chronic Kidney Disease Patients | ||||
| Sohag Medical Journal | ||||
| Volume 28, Issue 2, 2024, Page 151-159 PDF (973.33 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/smj.2024.268250.1453 | ||||
 View on SCiNiTO | ||||
| Authors | ||||
mohammed khalaf morsi  1; nayel abd elhamed zaki2; usama ahmed arafa3; Ahmed Hussein4
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| 1internal medicine department, sohag faculty of medicine, sohag university , sohag , Egypt | ||||
| 2internal medicine department, faculty of medicine, sohag university , Sohag city, Egypt | ||||
| 3internal medicine department , faculty of medicine, sohag university | ||||
| 4cardiology unit, internal medicine department , faculty of medicine, sohag university | ||||
| Abstract | ||||
| Impact Of Type 2 Diabetes Mellitus On Activated Partial Thromboplastin Time and Serum Fibrinogen In Non-dialysis Chronic Kidney Disease Patients ABSTRACT Background: due to abnormalities in coagulation and hypo-fibrinolysis, diabetes mellitus is linked to an increased risk of thrombotic complications. In patients with chronic kidney disease (CKD), pro- and anti-hemostatic factors are disrupted, leading to both bleeding and thrombotic complications. However, few studies have shown how diabetes mellitus affects serum fibrinogen levels and APTT in non-dialysis CKD patients. Aim of the work: To investigate impact of type 2 DM on APTT and serum fibrinogen in Non-dialysis CKD patients. Patients and methods: 150 patients classified into 3 groups each group included 50 patients, group with DM only patients, group with CKD only patients and group with CKD and DM patients , demographic data, APTT, serum fibrinogen , HbA1c and eGFR were done for all patients. Results: Combining DM with CKD led to a significant increase in serum fibrinogen level (p<0.0001) and a reduction in APTT (p<0.0001). Serum fibrinogen also showed a positive correlation with HbA1c and eGFR (p<0.0001, r = 0.8 ) (P <0.002, r = 0.26) and a negative correlation (P<0.0001, r = -0.66 ) ( P< 0.0001, r = -0.50) with HbA1c and eGFR. Conclusion: Serum fibrinogen, APTT, and glycemic state should all be closely watched in non-dialysis CKD patients, This can help lower the risk of thrombosis in the future. Keywords: Type 2 diabetes mellitus; APTT; Fibrinogen ; Non-dialysis chronic kidney disease . | ||||
| Keywords | ||||
| Type 2 diabetes mellitus; APTT; Fibrinogen; Non-dialysis chronic kidney disease | ||||
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