The "cardiometabolic index" as a new marker determined by adiposity and blood lipids for discrimination of patients with type 2 diabetes mellitus | ||||
Sohag Medical Journal | ||||
Article 11, Volume 22, Issue 2, July 2018, Page 85-90 PDF (59.16 K) | ||||
Document Type: Original Article | ||||
DOI: 10.21608/smj.2018.35027 | ||||
View on SCiNiTO | ||||
Authors | ||||
Zeinab M Mahmoud1; Ahmed A Allam1; Ahmed S Mahmoud2; Shaimaa A Selim1 | ||||
1Department of clinical and chemical pathology, Sohag Faculty of Medicine, Sohag University. | ||||
2Department of Clinical and Chemical pathology, Sohag Faculty of Medicine, Sohag University. | ||||
Abstract | ||||
*background:Diabetes is a well-established independent risk factor for cardiovascular diseases (CVD). Compared with non-diabetic individuals, diabetic patients have 2 to 4 times increased risk for stroke and death from heart disease. *aim: - Studying the relationship between cardiometabolic index and severity of diabetes. *patients&methods: Cross sectional stydy, was carried out in the Clinical Pathology Department, Faculty of medicine, Sohag university hospital, on 200 patients known to have type 2 diabetes mellitus the outpatient diabetic clinic, in addition to 100 healthy individuals with the mean age as it was 53 years in all groups. *results: In our study group 2 (diabetic obese) showed the worst values for both lipid profileand HbA1c, followed by group 1 (diabetic non obese) and group 3 (controls) showed the best figures. Also BMI was much higher among group 2 (diabetic obese) compared to both groups 1 and 3. *conclusion:Dyslipidemia increases the risk of CVD in type-2 diabetic patients. | ||||
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References | ||||
1- Harati H, Hadaegh F, Saadat N, Azizi F: Population-based incidence of type 2 diabetes and its associated risk factors: results from a six-year cohort study in Iran. MBC Public Health 2009,9:186. 2- Mooradian AD. Dyslipidemia in type 2 diabetes mellitus. Nat Clin Pract Endocrinol Metab 2009;5:150-9. 3- Jonathan D.Schofield, Yifen Liu, Prasanna Rao-Balakrishna, Rayaz A. Malik and Handrean Soran. Diabetes Dyslipidemia: Diabetes therapy, 2016 Jun; 7(2): 203–219. 4- Haoyu Wang , Yintao Chen, Gouzhe Sun, Pengyu Jia, Hao Qian and Yingixian Sun: Validity of cardiometabolic index, lipid accumulation product, and body adiposity index in predicting the risk of hypertension in Chinese population.Postgraduate Medicine. Volume 130, 2018. 5- McLaughlin T, Reaven G, Abbasi F, Lamendola C, Saad M, Waters D, et al. Is there a simple way to identify insulin-resistant individuals at increased risk of cardiovascular disease? Am J Cardiol 2005;96: 399-404. 6- Cordero A, Laclaustra M, Leon M, Casasnovas JA, Grima A, Luengo E, et al. Comparison of serum lipid values in subjects with and without the metabolic syndrome. Am J Cardiol 2008;102:424-8. 7- Gruson E, Montaye M, Kee F, Wagner A, Bingham A, Ruidavats JB, et al. Anthropometric assessment of abdominal obesity and coronary heart disease risk in men; the PRIME study. Heart 2010;96:136-40. 8- Lee CM, Huxley RR, Wildman RP, Woodward M. Indices of abdominal obesity are better discriminators of cardiovascular risk factors than BMI: a meta-analysis. J Clin Epidemiol 2008;61:646-53. 9- Ashwell M, Gunn P, Gibson S. Waist-to-height ratio is a better screening tool than waist circumference and BMI for adult cardiometabolic risk factors: systematic review and meta-analysis, Obes Rev 2012;13:275-86. 10- Lorenzo C, Hartnett S, Hanley AJ, et al. Impaired fasting glucose and impaired glucose tolerance have distinct lipoprotein and apolipoprotein changes: the insulin resistance atherosclerosis study. J Clin Endocrinol Metab 2013;98(4):1622–30. 11- Arca M, Pigna G, Favoccia C. Mechanisms of diabetic dyslipidemia: relevance for atherogenesis. Curr Vasc Pharmacol 2012;10(6):684–6. 12- Shah S, Casas JP, Drenos F, et al. Causal relevance of blood lipid fractions in the development of carotid atherosclerosis:Mendelian randomization analysis. Circ Cardiovasc Genet 2013;6(1):63–72. 13- Kumar A, Kulshrestha M, TripathiA, Sharma M and Kartikeya. A study of correlation between carotid intima - media thickness and diastolic dysfunction in asymptomatic type 2 Diabetics.IJCMR. 2016;3:1458-60. 14- Ozder A. Lipid profile abnormalities seen in T2DM patients in primary healthcare in Turkey: a cross-sectional study. Lipids Health Dis. 2014;13:183. 15- Jain H, Shetty V, Singh GS, et al. A Study of Lipid Profile in Diabetes Mellitus. 2016, December, 2321-6379. 16- Abdel-Aal NM, Ahmad AT, Froelicher ES, Batieha AMS, Hamza MM, Ajlouni KM. Prevalence of dyslipidemia in patients with type 2 diabetes in Jordan. Saudi Med. J. 2008;29(10):1423-8. 17- Seyoum B, Abdulkadir J, Berhanu P, Feleke Y, Mengistu Z, Worku Y, Ayana G. Analysis of serum lipids and lipoproteins in Ethiopian diabetic patients. Ethiop. Med. J. 2003;41(1):1-8. 18- Siraj ES, Seyoum B, Saenz C, Abdulkadir J. Lipid and lipoprotein profiles in Ethiopian patients with diabetes mellitus. Metabolism 2006;55(6):706-10. 19- Addisu YM. Lipid profile among diabetes patients in Gaborone, Botswana. S. Afr. Med. J. 2006;96(2):147-8. Collins R, Armitage J, Parish S, Sleigh P. Heart Protection Study Collaborative Group. MRC/BHF Heart Protetion Study of cholesterol lowering with simvastatin in 5963 people with diabates: a randomised placebo-controlled trial. Lancet 2003;361:2005-16. | ||||
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