Characterization and drug delivery properties of gamma irradiated poly (vinyl alcohol)/methylcellulose (PVA/MC) blends | ||||
| The International Conference on Chemical and Environmental Engineering | ||||
| Article 1, Volume 8, 8th International Conference on Chemical & Environmental Engineering, April 2016, Page 2-22 PDF (1.01 MB) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/iccee.2016.35028 | ||||
 View on SCiNiTO | ||||
| Authors | ||||
| Abdel Wahab M. El-Naggar1; Magdy M. Senna1; Tahia A. Mostafa2; Reham H. Helal1 | ||||
| 1Radiation Chemistry Department, National Center for Radiation Research and Technology, B.O. Box 29 Nasr City, Atomic Energy Authority, Cairo Egypt. | ||||
| 2Chemistry Department, College for Girls, Ain Shams University, Cairo, Egypt. | ||||
| Abstract | ||||
| Abstract In this work, polymer blends based on poly(vinyl alcohol) (PVA) and different ratios (5 and 10 wt%) of methylcellulose (MC) were prepared into films by solution casting using water as a common solvent, and gamma irradiated at different doses. The blends before and after gamma irradiation were loaded with Doxycycline hyclate (DOX-h) as drug model. The effect of DOX-h drug on the chemical and physical properties was first investigated in terms of gel content, swelling and surface morphology by scanning electron microscopy (SEM). The gamma irradiated PVA/MC blends was evaluated for the possible use in drug delivery systems. In this respect, the release profiles of DOX-h from PVA/MC were investigated. It was found that the accumulated drug release from the blends increases with time to reach ~60% after 1 h at pH of 2 compared to ~100% at pH of 8. | ||||
| Keywords | ||||
| Poly (vinyl alcohol); Methylcellulose; gamma radiation; Gel fraction; Swelling characters; Drug delivery | ||||
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