Potential anticancer, antiviral and antimicrobial effect of Red Sea soft coral. | ||||
| Egyptian Journal of Chemistry | ||||
| Articles in Press, Accepted Manuscript, Available Online from 16 April 2024 | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/ejchem.2024.251493.8928 | ||||
 View on SCiNiTO | ||||
| Authors | ||||
Asmaa M. Abdel-Tawab  1, 2; El sayed A. E. Hamed3; Samia S. Abouelkheir4
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| 1National Institute of Oceanography and Fisheries (NIOF), Egypt, Marine Biotechnology and Natural Products Laboratory. | ||||
| 2Chemistry of Medicinal Plants Department, National Research Centre, 33 El-Bohouth St., Dokki, Giza, 12622, Egypt. | ||||
| 3National Institute of Oceanography and Fisheries (NIOF), Egypt, Invertebrate Aquaculture Laboratory | ||||
| 4National Institute of Oceanography and Fisheries (NIOF), Egypt, Microbiology Laboratory. | ||||
| Abstract | ||||
| Sarcophyton Convolutum extract (S) is rich source of bioactive secondary metabolite. In this article we report identification of major components and study antimicrobial, anticancer and antiviral activities of non-polar Sarcophyton Convolutum extract. Results demonstrated that S. Convolutum extract (S) has strong bactericidal effect against P. aeruginosa ATCC 15442 recording MIC value about 0.05µg/mL. S. Convolutum extract (S) showed cytotoxicity against hepatocellular carcinoma cell line (HepG2), human colorectal adenocarcinoma (CaCo2), breast cancer cell line (MCF-7), and pulmonary adenocarcinoma (A549) and recorded IC50 of 102.73, 100.62, 86.68 and 81.64 while antiviral activity towards HSV-1 and HAV virus at the maximum nontoxic concentration was 32.69% and 11.53%, respectively. GCMS analysis of S. Convolutum extract (S) showed about 25 compounds about 45.31% of extract is sesquiterpene, 47.53 % fatty acid derivatives 3.13% steroids and 2.2% is retinal diterpene. Our in vitro study indicates that sesquiterpene rich softcoral S. Convolutum extract (S) is a promising anticancer and antimicrobial agent but weak antiviral agent. | ||||
| Keywords | ||||
| Sarcophyton Convolutum; sesquiterpene; anticancer; antimicrobial; antiviral | ||||
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