IMMUNOHISTOCHEMICAL EXPRESSION OF ESTROGEN RECEPTORS AS PROGNOSTIC MARKER AND CORRELATION WITH CLINICOPATHOLOGICAL PARAMETERS IN HUMAN ENDOMETRIAL ADENOCARCINOMA
Mohamed, S., Amin, A., salih, A., Al-Qadasi, S., Sultan, R. (2024). IMMUNOHISTOCHEMICAL EXPRESSION OF ESTROGEN RECEPTORS AS PROGNOSTIC MARKER AND CORRELATION WITH CLINICOPATHOLOGICAL PARAMETERS IN HUMAN ENDOMETRIAL ADENOCARCINOMA. EKB Journal Management System, 6(2), 101-114. doi: 10.21608/jmals.2024.350487
Saeed Mahmoud Saeed Mohamed; Afaf Mosaad Amin; Aisha Mohmmed Osman salih; Sabah Ali Mugahed Al-Qadasi; Roa Mohmed Mahmoud Sultan. "IMMUNOHISTOCHEMICAL EXPRESSION OF ESTROGEN RECEPTORS AS PROGNOSTIC MARKER AND CORRELATION WITH CLINICOPATHOLOGICAL PARAMETERS IN HUMAN ENDOMETRIAL ADENOCARCINOMA". EKB Journal Management System, 6, 2, 2024, 101-114. doi: 10.21608/jmals.2024.350487
Mohamed, S., Amin, A., salih, A., Al-Qadasi, S., Sultan, R. (2024). 'IMMUNOHISTOCHEMICAL EXPRESSION OF ESTROGEN RECEPTORS AS PROGNOSTIC MARKER AND CORRELATION WITH CLINICOPATHOLOGICAL PARAMETERS IN HUMAN ENDOMETRIAL ADENOCARCINOMA', EKB Journal Management System, 6(2), pp. 101-114. doi: 10.21608/jmals.2024.350487
Mohamed, S., Amin, A., salih, A., Al-Qadasi, S., Sultan, R. IMMUNOHISTOCHEMICAL EXPRESSION OF ESTROGEN RECEPTORS AS PROGNOSTIC MARKER AND CORRELATION WITH CLINICOPATHOLOGICAL PARAMETERS IN HUMAN ENDOMETRIAL ADENOCARCINOMA. EKB Journal Management System, 2024; 6(2): 101-114. doi: 10.21608/jmals.2024.350487

IMMUNOHISTOCHEMICAL EXPRESSION OF ESTROGEN RECEPTORS AS PROGNOSTIC MARKER AND CORRELATION WITH CLINICOPATHOLOGICAL PARAMETERS IN HUMAN ENDOMETRIAL ADENOCARCINOMA

Journal of Medical and Life Science
Volume 6, Issue 2, June 2024, Page 101-114  XML PDF (1.5 MB)
Document Type: Original Article
DOI: 10.21608/jmals.2024.350487
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Authors
Saeed Mahmoud Saeed Mohamed email 1; Afaf Mosaad Amin2; Aisha Mohmmed Osman salih3; Sabah Ali Mugahed Al-Qadasi4; Roa Mohmed Mahmoud Sultan5
1Assistant Professor of Histopathology and Cytology Department, Faculty of Medical Laboratory Sciences, West Kurdofan University, Sudan.
2Professor of Histochemistry and Cell Biology Department, Medical Research Institute, University of Alexandria, Egypt.
3Assistant Professor of Biology and Biotechnology Department (Animal Physiology), Faculty of Science and Technology, Al Neelain University, Khartoum-Sudan
4Assistant Professor of Histology, Anatomy and Histology Department, Faculty of Medicine and Health Sciences, Sana'a University, Sana'a, Yemen.
5Lecturer of Histopathology and Cytology Department, Faculty of Medical Laboratory Sciences, Sudan International University, Khartoum- Sudan.
Abstract
In human steroid-sensitive tissue, Estrogen receptors (ERs) have been demonstrated at the mRNA and/or protein levels by using molecular biology and immunohistochemistry techniques. Estrogen receptors are present in endometrial hyperplasia and neoplastic endometrium. The present work aimed to compare the expression of ER as a prognostic biomarker in human endometrial adenocarcinoma versus benign tumors and normal endometrial tissues as well as their correlation with different pathological and histological parameters. The immunohistochemical technique was used to examine the expression of ER in normal, benign as well as in endometrial adenocarcinoma. Present results showed higher expression of ER in endometrial adenocarcinoma compared to normal and benign endometrial tissues.
Keywords
ER prognostic marker; Estrogen receptors; endometrial adenocarcinoma
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