Advances in Prediction of Neonatal Hyperbilirubinemia severity Using Cord Blood Hydrogen Peroxide | ||||
| Zagazig University Medical Journal | ||||
| Volume 30, Issue 1.3, March and April 2024, Page 286-292 PDF (1.14 MB) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/zumj.2024.280109.3294 | ||||
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| Authors | ||||
amani abdelaziz ahmed  1; Amal saeed elshal2; Ahmed Tarek Abdelbar3; Mona Mohammed Mohammed Ali Elsharkawy4
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| 1lecturer of pediatrics faculty of medicine zagazig university | ||||
| 2Assistant professor of biochemistry, faculty of medicine, zagazig university | ||||
| 3internship ,faculty of medicine , zagazig university | ||||
| 4Pediatric Department, Faculty of Medicine, Zagazig University, Sharkia, Egypt | ||||
| Abstract | ||||
| Background Unconjugated hyperbilirubinemia is the most common cause of hospital admissions and readmissions among the newborns. Aim of the work: Levels of hydrogen peroxide in cord blood can be used to confirm the predictive warning sign of neonatal hyperbilirubinemia and identify which babies require follow-up leaving the hospital. Patients and methods a cross-sectional study involved 30 healthy neonates. They were classified into two groups according to bilirubin level at the 5th day: less severe hyperbilirubinemia with a bilirubin level ≤ 17 mg/dl and severe hyperbilirubinemia with a bilirubin level > 17 mg/dl. Measurement of hydrogen peroxide in cord blood, at birth, and on the third and fifth days of life by colorimetric method. Results in our study show that at the cutoff point of cord blood hydrogen peroxide ≥2.685 uMol/L, sensitivity was 90.0%, specificity was 83.3%, predicted values (both positive and negative) were 78.3% and 92.6%, positive and negative likelihood ratios were 5.4 and 0.12, and accuracy was 86.0%. Conclusion: The levels of cord hydrogen peroxide and further sampling were considerably greater in neonates with severe hyperbilirubinemia. It is therefore possible to identify a subset of newborns who may be at risk of jaundice and require phototherapy or exchange at delivery by measuring the amounts of hydrogen peroxide in the umbilical cord blood. | ||||
| Keywords | ||||
| Key words: neonatal jaundice; sever hyperbilirubinemia; hydrogen peroxide and fullterm | ||||
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