Evaluation of The Efficacy of Aflibercept versus Mitomycin C in Trabeculectomy in Cases of Primary Open Angle Glaucoma | ||||
| International Journal of Medical Arts | ||||
| Article 5, Volume 6, Issue 3, March 2024, Page 4196-4207 PDF (2.06 MB) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/ijma.2023.243536.1843 | ||||
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| Authors | ||||
Abd Elmaksoud Hussien Abd Elmaksoud  1; Younis Alsaied Abd Elhafez1; Sayed Abbas Sayed2; Ali A. Ghali1
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| 1Department of Ophthalmology, Damietta Faculty of Medicine, Al-Azhar University, Damietta, Egypt | ||||
| 2Department of Ophthalmology, Faculty of Medicine, Al-Azhar University, Cairo, Egypt | ||||
| Abstract | ||||
| Background: Post-operative scarring at the bleb site is a major factor in whether or not a trabeculectomy is successful. Mitomycin C and anti-vascular endothelial growth factor drugs like Aflibercept have been frequently used as supplementary treatments to trabeculectomy. Aim of the Study: This study aims to compare the efficacy of aflibercept and mitomycin c in trabeculectomy in patients with primary open-angle glaucoma. Patients and Methods: This prospective interventional study was carried out in Al-Azhar University Hospital in New Damietta from 2021 to 2023 on 40 patients with uncontrollable bilateral primary open angle glaucoma. Patients were divided into 2 groups each patient was represented in each group with one eye: Group 1, Included 20 eyes with medically uncontrolled primary open-angle glaucoma in which sub scleral trabeculectomy with intraoperative mitomycin C [0.3mg/1ml] topical application was done. Group 2, Included 20 eyes with medically uncontrolled primary open-angle glaucoma in which subscleral trabeculectomy with intraoperative subconjunctival single dose of Eylea [2 mg / 0.05 mL] was done. Results: According to the IOP, we found a statistically significant reduction in the IOP from 25 [23-28] mmHg in group 1 and 25 [23-28] mmHg in group 2 at the baseline to 14 [13-15] mmHg in group 1 and 16 [15-16] mmHg in group 2 at 12 months postoperative [P = 0.001]. In terms of the Bleb evaluation, the Mainz score was used for the Bleb assessment all over the follow-up periods. It consists of seven main domains, bleb height, peripheral vascularity, central vascularity, transparency, microcyst formation, and conjunctival mobility. We found no statistically significant difference between the 2 groups as regards all Mainz domains over the follow-up periods [P > 0.05 for all]. Conclusion: The use of intraoperative subconjunctival single-dose Aflibercept in trabeculectomy is safe effective and comparable to the use of MMC in terms of the advantage of avoiding the potentially dangerous complications related to MMC use. | ||||
| Keywords | ||||
| Aflibercept; Eylea; Mitomycin c; Trabeculectomy; Primary open-angle glaucoma | ||||
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