Dexmedetomidine Versus Ketamine Infusion for Reducing Intra and Post Operative Opioid Consumption in Obese Patients Undergoing Abdominal Surgeries
Kamal, N., El-Aasar, N., El-Dorgham, L., Ahmed, A. (2024). Dexmedetomidine Versus Ketamine Infusion for Reducing Intra and Post Operative Opioid Consumption in Obese Patients Undergoing Abdominal Surgeries. EKB Journal Management System, (), -. doi: 10.21608/zumj.2024.281508.3318
Nour Ali Mostafa Kamal; Neveen Mahmoud El-Aasar; Lobna Taha El-Dorgham; Amany Fouad Ahmed. "Dexmedetomidine Versus Ketamine Infusion for Reducing Intra and Post Operative Opioid Consumption in Obese Patients Undergoing Abdominal Surgeries". EKB Journal Management System, , , 2024, -. doi: 10.21608/zumj.2024.281508.3318
Kamal, N., El-Aasar, N., El-Dorgham, L., Ahmed, A. (2024). 'Dexmedetomidine Versus Ketamine Infusion for Reducing Intra and Post Operative Opioid Consumption in Obese Patients Undergoing Abdominal Surgeries', EKB Journal Management System, (), pp. -. doi: 10.21608/zumj.2024.281508.3318
Kamal, N., El-Aasar, N., El-Dorgham, L., Ahmed, A. Dexmedetomidine Versus Ketamine Infusion for Reducing Intra and Post Operative Opioid Consumption in Obese Patients Undergoing Abdominal Surgeries. EKB Journal Management System, 2024; (): -. doi: 10.21608/zumj.2024.281508.3318

Dexmedetomidine Versus Ketamine Infusion for Reducing Intra and Post Operative Opioid Consumption in Obese Patients Undergoing Abdominal Surgeries

Zagazig University Medical Journal
Articles in Press, Accepted Manuscript, Available Online from 18 April 2024  XML
Document Type: Original Article
DOI: 10.21608/zumj.2024.281508.3318
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Authors
Nour Ali Mostafa Kamal email 1; Neveen Mahmoud El-Aasar2; Lobna Taha El-Dorgham2; Amany Fouad Ahmed2
1Anesthesia, Intensive Care and Pain Management Department, Faculty of Medicine - Zagazig University, Egypt
2Anesthesia, Intensive Care and Pain Management Department, Faculty of Medicine - Zagazig University, Egypt.
Abstract
Background: Dexmedetomidine possesses sedative and analgesic effects and is a selective α-2 adrenoceptor agonist. Researchers have been particularly curious about the role of ketamine in the contemporary opioid crisis. This study aimed to evaluate and compare between dexmedetomidine infusion versus ketamine infusion for reducing opioid consumption among obese patients undergoing abdominal surgeries.

Methods: We conducted this prospective double blinded randomized controlled trial on seventy-eight obese patients of class I&II undergoing abdominal surgeries. They were categorized in three groups (26 cases in each group): Group C (Control): received 0.9% normal saline, Group D (Dexmedetomidine): after bolus of 0.5 µcg/kg, they received dexmedetomidine infusion (4µcg/mL), Group K (Ketamine): after bolus of 0.3 mg/kg they received ketamine infusion (2 mg/mL). The intraoperative (total dose of fentanyl and hemodynamics) and postoperative (numeric rating scale (NRS), Modified Observer’s assessment of alertness/sedation scale (MOAS/S) and rescue analgesic dose) were evaluated.

Results: The Dexmedetomidine group showed highly significant (p<0.001) better MOAS\S score than the other two groups immediately postoperative and then control group after 10 minutes. The Ketamine group had significant (p≤0.05) better NRS score than the Dexmedetomidine group at 6 and 12 hours. The Ketamine group needed highly significant (P ≤0.001) longer time to first require analgesic compared to the control group and significantly (P <0.05) longer than the Dexmedetomidine group.

Conclusion: Dexmedetomidine and ketamine could effectively aid in pain management among obese patients undergoing abdominal surgery.
Keywords
Dexmedetomidine; Ketamine; Midazolam; opioid consumption; obese patients
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