Serum Levels of Soluble Fractalkine in Patients with Systemic Lupus Erythematosus | ||||
| Bulletin of Egyptian Society for Physiological Sciences | ||||
| Article 6, Volume 33, Issue 1, June 2013, Page 73-84 PDF (346.6 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/besps.2013.35098 | ||||
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| Authors | ||||
| Dalia Shaheen* 1; Hisham Habib2; Doaa Shahin3 | ||||
| 1Medical Biochemistry Department, Faculty of Medicine, Mansoura University | ||||
| 2Rheumatology and Rehabilitation, Faculty of Medicine, Mansoura University. | ||||
| 3Clinical Pathology Departments, Faculty of Medicine, Mansoura University. | ||||
| Abstract | ||||
| Background: Fractalkine (Fkn)/CX3CL1 which is a unique member of the CX3C chemokine subfamily, and expressed on inflamed endothelium appears to possess immunoregulatory properties that affect inflammatory/immune cell interactions and inflammatory responses at sites of inflammation. Objective: The purpose of the present study was to determine the Fractalkine/CX3CL1 level in SLE patients and correlates that level with indices of disease activity and damage, trying to disclose its role in the pathogenesis of SLE. Methods: The study was carried on forty SLE patients (classified into 15 active and 25 inactive by using clinical and the BILAG disease activity index assessment), thirty patients with rheumatoid arthritis (RA) as disease control group and twenty healthy as control group. Levels of soluble Fkn were measured by enzyme-linked immunosorbent assay. Expression of Fkn /CX3CL1 was quantified by real-time polymerase chain reaction. Results: Both serum sFkn levels and mRNA expression of Fkn /CX3CL1 were significantly higher in patients with SLE compared with RA patients and healthy controls (P<0.05) and were significantly higher in SLE patients with active disease than in those with inactive disease. Also, serum levels of sFkn were positively correlated with disease activity, organ damage, anti–double-stranded DNA (anti-dsDNA) antibody titers, anti-Sm antibody titers, immune complex C1q levels, anti-phospholipid, anti-RNP and ESR level and negatively correlated with total hemolytic complement activity (CH50). Conclusion: sFkn and CX3CL1 mRNA expression play crucial roles in the pathogenesis of SLE and that sFkn may serve as a serologic inflammatory marker of disease activity and organ damage. | ||||
| Keywords | ||||
| Soluble Fractalkine (sFkn); Fractalkine (Fkn)/CX3CL1; SLE; disease activity | ||||
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