MALONDIALDEHYDE, TOTAL ANTIOXIDANT CAPACITY, AND TROPONIN I ROLE IN PREDICTING MORBIDITY AND MORTALITY OF CASES WITH CARDIOTOXICITY ADMITTED TO MENOUFIA POISON CONTROL CENTER.

Elagamy, Situhom Elsayed; Abd-Elhafiz, huda; mahfouz, marwa; ibrahem, fayrouz; elseidy, amira; maher, ghadeer; El-Farouny, Reham Hassan

doi:10.21608/ejfsat.2024.254895.1314

	MALONDIALDEHYDE, TOTAL ANTIOXIDANT CAPACITY, AND TROPONIN I ROLE IN PREDICTING MORBIDITY AND MORTALITY OF CASES WITH CARDIOTOXICITY ADMITTED TO MENOUFIA POISON CONTROL CENTER.
The Egyptian Journal of Forensic Sciences and Applied Toxicology
Volume 24, Issue 1, March 2024, Page 53-68 PDF (618.65 K)
Document Type: Original Article
DOI: 10.21608/ejfsat.2024.254895.1314
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Authors
Situhom Elsayed Elagamy¹; huda Abd-Elhafiz²; marwa mahfouz³; fayrouz ibrahem⁴; amira elseidy⁵; ghadeer maher³; Reham Hassan El-Farouny ¹
¹Forensic Medicine and Clinical Toxicology Department, Faculty of Medicine, Menoufia University
²Menoufia university
³menoufia university
⁴forensic medicine and clinical toxicology department, faculty of medicine, Menoufia University. Egypt
⁵forensic and toxicology department, faculty of medicine, menoufia university
Abstract
Background: Poisoning with substances that have cardiotoxic effects has become the major cause of early deaths globally. These substances include several compounds that are used for medical or non-medical purposes. The objective of the study was to assess the role of biomarkers like total antioxidant capacity (TAC), malondialdehyde (MDA), and troponin I (cTnI) in predicting morbidity and mortality of cases with acute cardiotoxicity arriving at the Menoufia poison control center. Methods: A cross sectional hospital-based comparative study included acutely poisoned cases with cardiotoxic substances (80 participants) who arrived at Menoufia Poison Control Centre (MPCC) over six months and a control group of 80 healthy individuals. Sociodemographic and intoxication characters were registered and a full clinical systemic examination was done. Blood samples were collected on admission to measure (MDA), (TAC), and (cTnI). Results: The mean age of the cases was 25.67±10.57 years and they were mostly females (72.5%), students (48.7%), and from rural areas (61.25%). 45.0% were intoxicated by phosphides. Theophylline was the most common cardiotoxic drug (20.0%). Suicide was the most common form of poisoning (78.75%). 68.8% of the cases survived, while the mortality rate was 31.2%. MDA and TAC were both sensitive and accurate in predicting the severity and mortality of cardiotoxic poisoned cases when assessed in the early hours of poisoning. On the other hand, cTn1 showed no significant changes in cases in comparison to the control healthy individuals. Conclusion: MDA and TAC are sensitive and specific biomarkers for predicting morbidity and mortality outcomes in acute cardiotoxic poisoning and were more efficient than cTn1 in the early hours of acute cardiotoxicity assessment.
Keywords
Malondialdehyde; Total antioxidant capacity; Troponin I; cardiotoxicity; prediction


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