Acquired Thrombophilia and its Association with Recurrent Miscarriages | ||||
| Evidence Based Women's Health Journal | ||||
| Articles in Press, Accepted Manuscript, Available Online from 22 April 2024 | ||||
| Document Type: Review Article | ||||
| DOI: 10.21608/ebwhj.2024.277306.1315 | ||||
 View on SCiNiTO | ||||
| Authors | ||||
Bahaaddin Ahmad Saber   1; Sakar Ahmad Abdullah 2
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| 1Bioengineering department, Faculty of science,Kahramanmaras university- Turkey. MLT department, Technical college, Erbil polytechnic university- Erbil-Iraq | ||||
| 2Medical Laboratory Department, College of health and medical technology, Sulaimani Polytechnic University, Sulaimani, Iraq | ||||
| Abstract | ||||
| Objection: The goal of this review is to explore how abortion and miscarriage agents impact the process of miscarriage. Acquired thrombophilia is a condition characterized by an increased tendency for abnormal blood clotting, distinct from the inherited or congenital form. This condition poses significant risks during pregnancy, contributing to complications such as early and late pregnancy loss, pre-eclampsia, recurrent miscarriage, placental abruption, and intrauterine growth restriction (IUGR), often culminating in maternal death. The leading causative agent of acquired thrombophilia is the anti-phospholipid syndrome, marked by the production of heterogeneous autoantibodies against various anticoagulation factors. Lupus anticoagulant (LAC) antibody, Anti-thrombomodulin, Anti-protein C, Anti-B2GP1, Anti-prothrombin, Anti-factor X, Anti-Phosphatidylserine/Prothrombin Antibodies, Anti-protein S, anti-Annexin V, and anti-cardiolipin antibody are among the diverse autoantibodies associated with this syndrome. However, predicting the specific complications faced by pregnant women based on these autoantibodies remains challenging. Hyperhomocysteinemia, another form of acquired thrombophilia, contributes to miscarriage by inducing vascular thrombosis through an imbalance in homocysteine-methionine metabolism. Elevated homocysteine levels can serve as an inflammatory biomarker, offering insights into the observation of cardiovascular diseases. Despite the progress in understanding acquired thrombophilia, the complex interplay of autoantibodies and hyperhomocysteinemia with pregnancy complications requires further investigation to enhance clinical management and preventive strategies. | ||||
| Keywords | ||||
| anti-phospholipid syndrome Thrombophilia; pregnancy loss anticoagulation factors; lupus anticoagulant (LAC) antibody | ||||
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