POTENTIAL THERAPEUTIC AND PROPHYLACTIC EFFECTS OF PURSLANE (PORTULACA OLERACEA) OIL EXTRACT IN MURINE SCHISTOSOMIASIS MANSONI | ||||
| Journal of the Egyptian Society of Parasitology | ||||
| Article 3, Volume 54, Issue 1, April 2024, Page 11-18 PDF (1021.02 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/jesp.2024.351282 | ||||
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| Authors | ||||
| MOSTAFA EL-SHAHAT MOSTAFA; MORSY R. M. GENEEDY; FATMA M. EL-LESSY | ||||
| Department of Parasitology, Faculty of Medicine (Damietta* and Cairo), Al-Azhar University, Egypt | ||||
| Abstract | ||||
| Schistosomiasis is a neglected tropical illness, relying on a single drug to treat, its efficacy decreased as drug resistant strains emerged due to widespread usage. The study evaluated the therapeutic and prophylactic effects of Purslane (Portulaca oleracea) oil extract in comparison to praziquantel (PZQ) on experimental S. mansoni-infected mice by measuring parasitological, antioxidant activity, immunological, and histopathological parameters. Mice were infected followed by a single oral dose of PZQ or daily Purslane oil extract for 15 days, six weeks postinfection. Purslane treated group induced significant reduction in mean worm burden, hepatic, and intestinal egg loads, serum levels of ALT, AST along with significant rise in CAT, SOD,GSH-R, GPx activities, TNF- α, IL-4, IL-10, dead eggs percentage, and moderate decrease in granuloma diameter. PZQ was more effective than purslane. Purslane's methanol extract has promising therapeutic but little prophylactic effects against S. mansoni. | ||||
| Keywords | ||||
| Schistosoma mansoni; Purslane oil extract; Praziquantel; Assessment | ||||
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