STUDY ON THERAPEUTIC EFFICACY OF LACTOFERRIN LOADED ON SILVERNANOPARTICLES AGAINST TRICHINELLA SPIRALIS PARENTERAL PHASE
EL-GHANNAM, A., EL HAMSHARY, A., ALI, I., FAWZY, M., NAGIB, M. (2024). STUDY ON THERAPEUTIC EFFICACY OF LACTOFERRIN LOADED ON SILVERNANOPARTICLES AGAINST TRICHINELLA SPIRALIS PARENTERAL PHASE. EKB Journal Management System, 54(1), 95-102. doi: 10.21608/jesp.2024.351360
AMIRA SALAH EL-GHANNAM; AZZA MOHAMMED SALAH EL-DEN EL HAMSHARY; IBRAHIM RABIE BAYOUMI ALI; MAHA MAMDOUH FAWZY; MARWA MOHAMMED NAGIB. "STUDY ON THERAPEUTIC EFFICACY OF LACTOFERRIN LOADED ON SILVERNANOPARTICLES AGAINST TRICHINELLA SPIRALIS PARENTERAL PHASE". EKB Journal Management System, 54, 1, 2024, 95-102. doi: 10.21608/jesp.2024.351360
EL-GHANNAM, A., EL HAMSHARY, A., ALI, I., FAWZY, M., NAGIB, M. (2024). 'STUDY ON THERAPEUTIC EFFICACY OF LACTOFERRIN LOADED ON SILVERNANOPARTICLES AGAINST TRICHINELLA SPIRALIS PARENTERAL PHASE', EKB Journal Management System, 54(1), pp. 95-102. doi: 10.21608/jesp.2024.351360
EL-GHANNAM, A., EL HAMSHARY, A., ALI, I., FAWZY, M., NAGIB, M. STUDY ON THERAPEUTIC EFFICACY OF LACTOFERRIN LOADED ON SILVERNANOPARTICLES AGAINST TRICHINELLA SPIRALIS PARENTERAL PHASE. EKB Journal Management System, 2024; 54(1): 95-102. doi: 10.21608/jesp.2024.351360

STUDY ON THERAPEUTIC EFFICACY OF LACTOFERRIN LOADED ON SILVERNANOPARTICLES AGAINST TRICHINELLA SPIRALIS PARENTERAL PHASE

Journal of the Egyptian Society of Parasitology
Article 12, Volume 54, Issue 1, April 2024, Page 95-102  XML PDF (1.33 MB)
DOI: 10.21608/jesp.2024.351360
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Authors
AMIRA SALAH EL-GHANNAM1; AZZA MOHAMMED SALAH EL-DEN EL HAMSHARY1; IBRAHIM RABIE BAYOUMI ALI2; MAHA MAMDOUH FAWZY1; MARWA MOHAMMED NAGIB1
1Department of Medical Parasitology, Faculty of Medicine, Benha University, Benha
2Department of Immunology and drug evaluation, Theodor Bilharz Research Institute, Giza, Egypt
Abstract
Globally trichinellosis (Trichinella species) is a risky parasitic zoonosis Anthelminthic such as
oral albendazole® and mebendazole® commonly used to treatment are poorly water soluble with
unfavo- rable bioavailability. This study evaluated the therapeutic efficacy of lactoferrin loaded
on silver nanoparticles on Trichinella spiralis infection in experimental infected mice by parasitological
and histopathological parameters. Mice were classified into 8 groups each of 5 mice.
G1: Non infected non treated (normal), G2: Infected non treated (infected control), G3: In-fected
and albendazole, treated, G4: Infected and lactoferrin treated, G5: Infected and silver nanoparticles
treated, G6: Infected and lactoferrin loaded on silver nanoparticles treated, G7: Infected
and albendazole & lactoferrin, & G8: Infected and albendazole combined with lactoferrin
loaded on silver nanoparticles treated.
The results showed a significant decrease in all treated groups, markedly in T. spiralis larval
muscles treated with combination of albendazole and lactoferrin loaded on silver nanoparticles
(92.39%), with muscles histopathological changes
Keywords
Trichinella spiralis; albendazole; lactoferrin; silver nanoparticles; histopathology
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