TOXOPLASMA GONDII IGG AVIDITY IN DISCRIMINATING BETWEEN ACUTE AND CHRONIC TOXOPLASMOSIS IN NEONATAL CHOLESTASIS | ||||
| Journal of the Egyptian Society of Parasitology | ||||
| Article 17, Volume 54, Issue 1, April 2024, Page 129-136 PDF (3.15 MB) | ||||
| DOI: 10.21608/jesp.2024.351365 | ||||
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| Authors | ||||
ASMAA FAHMY IBRAHIM 1; TAHANY ABD EL HAMEED SALEM2; MARWA AHMED GOUDA 1
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| 1Department of Clinical and Molecular Parasitology, Menoufia University, Egypt | ||||
| 2Department of Paediatric Hepatology, Gastroenterology, and Nutrition, National Liver Institute, Menoufia University, Egypt | ||||
| Abstract | ||||
| Toxoplasma IgM (IgM) is a sensitive indicator of primary toxoplasmosis; but with limited specificity, and it may occasionally be sustained in blood serum for extended periods, ranging from several months to years, following the first infection. The Toxo IgG avidity assay is a currently employed diagnostic method for accurately assessing the time it takes to acquire an infection and determining the initial T. gondii infection. This study evaluated Toxoplasma IgG avidity testing in new-borns diagnosed with cholestasis on 92 neonates presented with cholestasis, whose blood samples were assessed for the presence of toxoplasmosis using IgG and Toxo IgG Avidity ELISA tests. Biochemical changes including the lipid profile, liver and renal functions were also evaluated. ELISA test revealed Toxo IgG seropositivity at 52.2% (29.43±17.86IU/ml). Toxo IgG avidity tested low at 56.5%, high at 34.8%, and borderline at 8.7% (0.38 ±0.31) with a significant association (P<0.001) at a cut-off value of 0.315. IgG titre was significantly correlated with direct bilirubin (P=0.029), AST (P<0.001), ALT (P<0.001), ALP (P=0.041), PC (P=0.003), INR (P=0.041), urea (P=0.021), and triglyceride (P=0.022). Toxo IgG avidity showed a significant (P<0.001) negative association with total bilirubin, direct bilirubin, AST, ALT, PT, INR, and a significant positive association with PC (P<0.001), GGT (P=0.01). | ||||
| Keywords | ||||
| T. gondii; IgG avidity; Neonatal cholestasis; Lipid profile; Renal and liver functions | ||||
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