Molecular Biological Studies on Immune Responses Enhancement against HCV, the Role of Toll like Receptor
Gomaa, A., Abdel - Mageed, W., Talaat, R., Neamatallah, M., El-Bendary, M. (2018). Molecular Biological Studies on Immune Responses Enhancement against HCV, the Role of Toll like Receptor. EKB Journal Management System, 9(1), 27-30. doi: 10.21608/jacb.2018.35154
Asmaa Gomaa; wael Abdel - Mageed; Roba Talaat; mostafa Neamatallah; mahmoud El-Bendary. "Molecular Biological Studies on Immune Responses Enhancement against HCV, the Role of Toll like Receptor". EKB Journal Management System, 9, 1, 2018, 27-30. doi: 10.21608/jacb.2018.35154
Gomaa, A., Abdel - Mageed, W., Talaat, R., Neamatallah, M., El-Bendary, M. (2018). 'Molecular Biological Studies on Immune Responses Enhancement against HCV, the Role of Toll like Receptor', EKB Journal Management System, 9(1), pp. 27-30. doi: 10.21608/jacb.2018.35154
Gomaa, A., Abdel - Mageed, W., Talaat, R., Neamatallah, M., El-Bendary, M. Molecular Biological Studies on Immune Responses Enhancement against HCV, the Role of Toll like Receptor. EKB Journal Management System, 2018; 9(1): 27-30. doi: 10.21608/jacb.2018.35154

Molecular Biological Studies on Immune Responses Enhancement against HCV, the Role of Toll like Receptor

Journal of Agricultural Chemistry and Biotechnology
Article 4, Volume 9, Issue 1, January 2018, Page 27-30  XML PDF (206.62 K)
Document Type: Original Article
DOI: 10.21608/jacb.2018.35154
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Authors
Asmaa Gomaa1; wael Abdel - Mageed2; Roba Talaat2; mostafa Neamatallah3; mahmoud El-Bendary3
1Faculty of science, AlAzhar University
2Genetic Engineering and Biotechnology Research Institute, Sadat University.
3Faculty of Medicine Mansoura University
Abstract
Epidemic disease with hepatitis C virus (HCV) was raised by scanty immune restraint. Empirical facts propose that low activation of TLRs 2-4 sensors participates to epidemic disease. We predestined the allocation of Single nucleotide Polymorphism (SNPs) in the TLR2 Arg677Trp in epidemic HCV disease and minus HCV sets. This research purposes to discuss the modulation of genetic ethnic polymorphisms of TLR2 gene in the epidemic HCV disease Egyptian positive HCV.  TLR2 Arg677Trp rs121917864 (C/T) were genotyped in 549 positive HCV and 519 negative HCV sets. The combination analysis proved that the having of rare allele T of TLR2 Arg677Trp could have a low significant risk for epidemic HCV disease (OR= 1.5206 95%CI 1.1521 to 2.0069) and P = 0.0031.
Keywords
Polymorphism; TLR; HCV and SNPs
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