Molecular Detection of Monocyte Chemotactic Protein-1 gene Polymorphism in Patients with Spontaneous Bacterial Peritonitis
Salama, M., Sabry, D., Ahmed, R., Taha, F., Wadie, M. (2013). Molecular Detection of Monocyte Chemotactic Protein-1 gene Polymorphism in Patients with Spontaneous Bacterial Peritonitis. EKB Journal Management System, 33(1), 85-92. doi: 10.21608/besps.2013.35178
Maysa Salama; Dina Sabry; Rasha Ahmed; Fatma Taha; Miriam Wadie. "Molecular Detection of Monocyte Chemotactic Protein-1 gene Polymorphism in Patients with Spontaneous Bacterial Peritonitis". EKB Journal Management System, 33, 1, 2013, 85-92. doi: 10.21608/besps.2013.35178
Salama, M., Sabry, D., Ahmed, R., Taha, F., Wadie, M. (2013). 'Molecular Detection of Monocyte Chemotactic Protein-1 gene Polymorphism in Patients with Spontaneous Bacterial Peritonitis', EKB Journal Management System, 33(1), pp. 85-92. doi: 10.21608/besps.2013.35178
Salama, M., Sabry, D., Ahmed, R., Taha, F., Wadie, M. Molecular Detection of Monocyte Chemotactic Protein-1 gene Polymorphism in Patients with Spontaneous Bacterial Peritonitis. EKB Journal Management System, 2013; 33(1): 85-92. doi: 10.21608/besps.2013.35178

Molecular Detection of Monocyte Chemotactic Protein-1 gene Polymorphism in Patients with Spontaneous Bacterial Peritonitis

Bulletin of Egyptian Society for Physiological Sciences
Article 7, Volume 33, Issue 1, June 2013, Page 85-92  XML PDF (289.92 K)
Document Type: Original Article
DOI: 10.21608/besps.2013.35178
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Authors
Maysa Salama* 1; Dina Sabry1; Rasha Ahmed2; Fatma Taha1; Miriam Wadie1
1Medical Biochemistry and Molecular Biology, Faculty of Medicine, Cairo University
2Department of Tropical Medicine, Faculty of Medicine, Cairo University
Abstract
Backgrounds and Aim: Patients with cirrhosis and ascites show a higher susceptibility
to bacterial infections,Monocyte Chemotactic Protein-1(MCP-1) secretion is upregulated
during chronic hepatitis and correlates with the severity of hepatic
inflammation. We thought to confirm the association of the functional MCP-1 promoter
polymorphism (A-2518G) with spontaneous bacterial peritonitis (SBP). Methods: 50
patients with post-hepatitis C virus liver cirrhosis and ascites categorized into two
groups, group I: 25 patients with SBP, group II: 25 patients free from SBP, in addition
a group of 20 healthy volunteers were included. We assessed the MCP-1 gene
polymorphism in blood. Results: Significant MCP-1 gene polymorphism was detected
in group I & II (p-value=0.001 & 0.02 respectively), group I was significantly
associated with AG genotype, group II with GG genotype when compared to healthy
volunteers (p-value=0.002 & 0.001 respectively), and G allele was significantly higher
in both groups (I & II) (p-value 0.005 & 0.001 respectively). Conclusion: MCP-1 GG
genotype and G allele in HCV infected patients may be associated with more advanced
stage of the disease. AG genotype may increase the susceptibility to spontaneous
bacterial peritonitis.
Keywords
genotype; allele; ascites; Liver cirrhosis; Gene expression
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