Circulating Retinol Binding Protein-4 and Total Thiols In Generalized and Abdominal Obesity Regarding; Monitors Of Cardiovascular Disease | ||||
| Bulletin of Egyptian Society for Physiological Sciences | ||||
| Article 8, Volume 33, Issue 1, June 2013, Page 93-106 PDF (244.17 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/besps.2013.35184 | ||||
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| Authors | ||||
| Salwa Dimitry* 1; Naglaa Idriss2; Ahmed Ahmed1; Eman Abdel Aal1 | ||||
| 1Cardiology Department, Faculty of Medicine, Assuit University | ||||
| 2Medical Biochemsitry Department, Faculty of Medicine, Assuit University | ||||
| Abstract | ||||
| Background: Retinol-binding protein 4 (RBP4) is an adipocyte-secreted hormone considered to link obesity with cardiovascular complications. The oxidative stress caused by overproduction of reactive oxygen species (ROS)) has been concerned in the pathophysiology of obesity. We evaluated serum RBP-4 and plasma total thiols (TT) in generalized obesity (GO) and abdominal obesity (AO) as regard to cardiovascular risk factors. Glycated hemoglobin (HbA1c), C- reactive protein (CRP) and lipid profile were also evaluated. Subjects and Methods: Sixty obese subjects were recruited [30 abdominally obese (AO) subjects (15 males and 15 females); their mean± SD of age was 49.5±5.5 years. Their waist circumference (WC) was > 102 cm for men or > 88 cm for women) and waist/hip ratio (WC divided by that of the hips of > 0.9 for men and > 0.85 for women)] and [30 generalized obese (GO) subjects (22 males and 8 females; their mean± SD of age was 42.5± 8 years), their body mass index (BMI) was ≥ 30-34.9 kg/m2, with normal WC]. Serum levels of RBP-4 were measured by ELISA, serum levels of TT were measured by colorimetric methods, blood HbA1c%, lipid profiles and CRP were also determined. Subjects with AO had significantly higher circulating RBP-4 and CRP levels compared to GO (p< 0.05 for each). Total thiols levels were significantly lower in AO subjects compared to GO (p< 0.05). Total serum cholesterol, triglycerides and HbA 1c% increased with BMI, WC and waist/hip ratio (WHR), but the relations were statistically insignificant. Conclusion: The study revealed that RBP-4 is autonomously related to visceral fat accumulations and cardiovascular diseases. The study also revealed the beneficial effect of TT against obesity and cardiovascular disease and the potential clinical applicability of RBP4 and total thiols in cardiovascular diseases. | ||||
| Keywords | ||||
| Retinol binding protein4-abdominal; obesity-generalized; obesity cardiovascular disease | ||||
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