Influence of MiR-126-3p and MiR-146a-5p Dysregulation on The Risk and Clinicopathological Features of Papillary Thyroid Cancer in Patients with Thyroid Nodules
Rashad, N., Abdel Aziz, E., abdelsamad, M., Mohey, N., Abd El-Fatah, A., mousa, M. (2024). Influence of MiR-126-3p and MiR-146a-5p Dysregulation on The Risk and Clinicopathological Features of Papillary Thyroid Cancer in Patients with Thyroid Nodules. EKB Journal Management System, 30(5), 1593-1604. doi: 10.21608/zumj.2024.282351.3328
Nearmeen Rashad; Eman Abdel Aziz; MONA abdelsamad; Nesreen M Mohey; Azza Hassan Abd El-Fatah; mayada mousa. "Influence of MiR-126-3p and MiR-146a-5p Dysregulation on The Risk and Clinicopathological Features of Papillary Thyroid Cancer in Patients with Thyroid Nodules". EKB Journal Management System, 30, 5, 2024, 1593-1604. doi: 10.21608/zumj.2024.282351.3328
Rashad, N., Abdel Aziz, E., abdelsamad, M., Mohey, N., Abd El-Fatah, A., mousa, M. (2024). 'Influence of MiR-126-3p and MiR-146a-5p Dysregulation on The Risk and Clinicopathological Features of Papillary Thyroid Cancer in Patients with Thyroid Nodules', EKB Journal Management System, 30(5), pp. 1593-1604. doi: 10.21608/zumj.2024.282351.3328
Rashad, N., Abdel Aziz, E., abdelsamad, M., Mohey, N., Abd El-Fatah, A., mousa, M. Influence of MiR-126-3p and MiR-146a-5p Dysregulation on The Risk and Clinicopathological Features of Papillary Thyroid Cancer in Patients with Thyroid Nodules. EKB Journal Management System, 2024; 30(5): 1593-1604. doi: 10.21608/zumj.2024.282351.3328

Influence of MiR-126-3p and MiR-146a-5p Dysregulation on The Risk and Clinicopathological Features of Papillary Thyroid Cancer in Patients with Thyroid Nodules

Zagazig University Medical Journal
Volume 30, Issue 5, August 2024, Page 1593-1604  XML PDF (1.63 MB)
Document Type: Original Article
DOI: 10.21608/zumj.2024.282351.3328
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Authors
Nearmeen Rashad email orcid 1; Eman Abdel Aziz2; MONA abdelsamad3; Nesreen M Moheyorcid 4; Azza Hassan Abd El-Fatah5; mayada mousa6
1ZAagazig university
2clinical pathology department, faculty of medicine, Zagazig University
3Medical analysis laboratory, Student Hospital, Zagazig University. Egypt.
4Radiodiagnosis department faculty of medicine Zagazig University
5Lecturer of Internal Medicine, Faculty of Medicine, Zagazig University
6zagazig university
Abstract
Background

Papillary thyroid cancer (PTC) is the most frequent endocrine cancer. Aberrant expression of miRNAs can increase the risk of thyroid cancer. We aimed to investigate the miR-126-3p and miR-146a-5p plasma levels in patients with thyroid nodules and to identify their associations with clinicopathological characteristics, and progression of PTC.

Methods: We enrolled 40 healthy control and forty patients with thyroid nodules; benign thyroid nodules (BTN), (n=30), and PTC(n=10). We analyzed miR-126-3p and miR-146a-5p levels by using real-time PCR.

Results: miR-126-3p expression level was downregulated in PTC patients (0.40±0.11) compared with BTN (0.58±0.12) and healthy subjects (0.87±0.31), P<0.001*Regarding miR-146a-5p, its level was upregulated in PTC patients (4.59±1.61

) compared with BTN (3.77±0.96) and healthy subjects (0.99±0.41), Additionally, miR-126-3p and miR-146b-5p levels were significantly associated with tumor progression, lymph node metastasis, TNM staging, and thyroid function tests. The diagnostic power of miR-126-3p in the prediction of PTC, the AUC was 0.860 with a sensitivity of 60 % and specificity of 87.3% at cutoff values =0.49. miR-146a-5p level in the prediction of PTC, the AUC was 0.742 with a sensitivity of 80 % and specificity of 74.3% at cutoff values =3.4.
Keywords
miR-146b-5p; MiR-126-3p; papillary thyroid cancer; benign thyroid nodules; real-time PCR
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